Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 18069..19245 Replicon chromosome
Accession NZ_CP094144
Organism Helicobacter pylori strain Hpfe029

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPG75_RS00075 Protein ID WP_245039344.1
Coordinates 18496..19245 (+) Length 250 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPG75_RS00070 Protein ID WP_245039343.1
Coordinates 18069..18506 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG75_RS00060 (MPG75_00060) 15672..16205 + 534 WP_245039342.1 hypothetical protein -
MPG75_RS00065 (MPG75_00065) 16216..17843 + 1628 Protein_11 RNA-directed DNA polymerase -
MPG75_RS00070 (MPG75_00070) 18069..18506 + 438 WP_245039343.1 Panacea domain-containing protein Antitoxin
MPG75_RS00075 (MPG75_00075) 18496..19245 + 750 WP_245039344.1 hypothetical protein Toxin
MPG75_RS00080 (MPG75_00080) 19521..20708 - 1188 WP_245039345.1 transcription termination factor NusA -
MPG75_RS00085 (MPG75_00085) 20796..21956 - 1161 WP_245039346.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 250 a.a.        Molecular weight: 29070.93 Da        Isoelectric Point: 5.9440

>T239278 WP_245039344.1 NZ_CP094144:18496-19245 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTMDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWFNLMVTIL
FVIGFVGEN

Download         Length: 750 bp

>T239278 NZ_LR890657:c3398708-3398310 [Serratia marcescens]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGTATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17263.35 Da        Isoelectric Point: 5.7221

>AT239278 WP_245039343.1 NZ_CP094144:18069-18506 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQDLRKDELETINYSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239278 NZ_LR890657:c3398941-3398708 [Serratia marcescens]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCACTGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References