Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ(toxin) |
| Location | 627155..627725 | Replicon | chromosome |
| Accession | NZ_CP094143 | ||
| Organism | Helicobacter pylori strain Hpfe032 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | MPG16_RS02965 | Protein ID | WP_245108815.1 |
| Coordinates | 627453..627725 (+) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | MPG16_RS02960 | Protein ID | WP_075653293.1 |
| Coordinates | 627155..627466 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPG16_RS02930 (MPG16_02930) | 622172..622408 | + | 237 | WP_000335478.1 | HypC/HybG/HupF family hydrogenase formation chaperone | - |
| MPG16_RS02935 (MPG16_02935) | 622427..623539 | + | 1113 | WP_245108812.1 | hydrogenase formation protein HypD | - |
| MPG16_RS02940 (MPG16_02940) | 623490..624011 | - | 522 | WP_245108813.1 | hypothetical protein | - |
| MPG16_RS02955 (MPG16_02955) | 624514..626739 | + | 2226 | WP_245108814.1 | Hop family adhesin BabA | - |
| MPG16_RS02960 (MPG16_02960) | 627155..627466 | + | 312 | WP_075653293.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
| MPG16_RS02965 (MPG16_02965) | 627453..627725 | + | 273 | WP_245108815.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| MPG16_RS02970 (MPG16_02970) | 627833..628357 | - | 525 | WP_001135602.1 | acyl-CoA thioesterase | - |
| MPG16_RS02975 (MPG16_02975) | 628498..629346 | + | 849 | WP_245108816.1 | SDR family oxidoreductase | - |
| MPG16_RS02980 (MPG16_02980) | 629339..630319 | + | 981 | WP_000921482.1 | iron ABC transporter permease | - |
| MPG16_RS02985 (MPG16_02985) | 630319..631086 | + | 768 | WP_000242367.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10614.67 Da Isoelectric Point: 9.7265
>T239277 WP_245108815.1 NZ_CP094143:627453-627725 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKTGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGVLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF
MLMIETSKKFDKDLKILVKTGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGVLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF
Download Length: 273 bp
>T239277 NZ_LR890657:2182105-2182201 [Serratia marcescens]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT
Antitoxin
Download Length: 104 a.a. Molecular weight: 12359.22 Da Isoelectric Point: 10.1678
>AT239277 WP_075653293.1 NZ_CP094143:627155-627466 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQVQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNADD
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQVQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNADD
Download Length: 312 bp
>AT239277 NZ_LR890657:c2182201-2182061 [Serratia marcescens]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|