Detailed information of TA system TA239275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 20295..21486
• Replicon: chromosome
• Accession: NZ_CP094143
• Organism: Helicobacter pylori strain Hpfe032

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG16_RS00075
• Protein ID: WP_245108512.1
• Coordinates: 20722..21486 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG16_RS00070
• Protein ID: WP_075707466.1
• Coordinates: 20295..20732 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG16_RS00065 (MPG16_00065)	18444..20069	+	1626	WP_245108950.1	RNA-directed DNA polymerase	-
MPG16_RS00070 (MPG16_00070)	20295..20732	+	438	WP_075707466.1	Panacea domain-containing protein	Antitoxin
MPG16_RS00075 (MPG16_00075)	20722..21486	+	765	WP_245108512.1	hypothetical protein	Toxin
MPG16_RS00080 (MPG16_00080)	21715..22902	-	1188	WP_120944327.1	transcription termination factor NusA	-
MPG16_RS00085 (MPG16_00085)	22990..24150	-	1161	WP_245108513.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29861.07 Da
• Isoelectric Point: 8.7873

>T239275 WP_245108512.1 NZ_CP094143:20722-21486 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKNVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKPIFWFNLMVIILFVIGFF
GELHIIQRLVSKYL

Nucleotide

• Length: 765 bp

>T239275 NZ_LR890657:c1187737-1187534 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGGTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17274.40 Da
• Isoelectric Point: 6.1226

>AT239275 WP_075707466.1 NZ_CP094143:20295-20732 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIKKCNEKSYWDLVKESHKEDGAWHKSFREDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239275 NZ_LR890657:c1188156-1187788 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
GACCTTGGGAGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACTTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAGACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG