Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 575268..575892 Replicon chromosome
Accession NZ_CP094142
Organism Helicobacter pylori strain Hpfe033

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG02_RS02775 Protein ID WP_231171737.1
Coordinates 575626..575892 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG02_RS02770 Protein ID WP_245075692.1
Coordinates 575268..575639 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG02_RS02750 (MPG02_02750) 571277..571798 - 522 WP_245075681.1 hypothetical protein -
MPG02_RS02765 (MPG02_02765) 572290..574515 + 2226 WP_245075690.1 Hop family adhesin BabA -
MPG02_RS02770 (MPG02_02770) 575268..575639 + 372 WP_245075692.1 hypothetical protein Antitoxin
MPG02_RS02775 (MPG02_02775) 575626..575892 + 267 WP_231171737.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG02_RS02780 (MPG02_02780) 575998..576522 - 525 WP_180425348.1 acyl-CoA thioesterase -
MPG02_RS02785 (MPG02_02785) 576662..577504 + 843 WP_245075694.1 SDR family oxidoreductase -
MPG02_RS02790 (MPG02_02790) 577497..578477 + 981 WP_000921452.1 iron ABC transporter permease -
MPG02_RS02795 (MPG02_02795) 578477..579244 + 768 WP_245075696.1 ABC transporter ATP-binding protein -
MPG02_RS02800 (MPG02_02800) 579314..580441 + 1128 WP_280636934.1 glycosyltransferase family 8 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10380.36 Da        Isoelectric Point: 10.0434

>T239274 WP_231171737.1 NZ_CP094142:575626-575892 [Helicobacter pylori]
MLKIKHHILYKKDFKKLIKNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T239274 NZ_LR890657:469797-470072 [Serratia marcescens]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGTCTGCTGGATCATCCTGAGTTAGGTAAGCCTTGGTATG
GGAAGGCACGTAAGTTGCTAATTAACAAGGCCTCCCTGTTGCTGGTGTATATCATCGTCGATGATGTTATTAAGGTTTTC
TCGATTGCCCACCAGCGTGAGAAATTTCCAAACTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14467.34 Da        Isoelectric Point: 5.9689

>AT239274 WP_245075692.1 NZ_CP094142:575268-575639 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLIHQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNGENLETIEDFSAWANEVKKEVNAEN

Download         Length: 372 bp

>AT239274 NZ_LR890657:469501-469788 [Serratia marcescens]
ATGGAAAGTCGCATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCGGAAGCTAAAGGAACGAC
ATTGAGTGAAGCCTGCCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCCGCGGAGGAGCACGAAAATTGGTTGA
AAGATAAGGTGGATGCAGCTTTTTCCCGTCTGCATGAGGGTAATGCTGTCTACCTTAGCCAACAAGAAGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATTAGAGCGAAATACGACCGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References