Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 611993..612563 Replicon chromosome
Accession NZ_CP094140
Organism Helicobacter pylori strain Hpfe035

Toxin (Protein)


Gene name relE Uniprot ID D0K031
Locus tag MPG83_RS02935 Protein ID WP_000928609.1
Coordinates 612291..612563 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2IKC6
Locus tag MPG83_RS02930 Protein ID WP_001133858.1
Coordinates 611993..612304 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG83_RS02900 (MPG83_02900) 607442..608074 - 633 WP_245071867.1 helicase DnaB modulator -
MPG83_RS02915 (MPG83_02915) 608473..610707 + 2235 WP_245071874.1 Hop family adhesin BabA -
MPG83_RS02920 (MPG83_02920) 611291..611668 + 378 WP_245071875.1 hypothetical protein -
MPG83_RS02925 (MPG83_02925) 611649..611915 + 267 WP_180621785.1 type II toxin-antitoxin system YafQ family toxin -
MPG83_RS02930 (MPG83_02930) 611993..612304 + 312 WP_001133858.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG83_RS02935 (MPG83_02935) 612291..612563 + 273 WP_000928609.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
MPG83_RS02940 (MPG83_02940) 612668..613192 - 525 WP_058338129.1 acyl-CoA thioesterase -
MPG83_RS02945 (MPG83_02945) 613332..614174 + 843 WP_245071876.1 SDR family oxidoreductase -
MPG83_RS02950 (MPG83_02950) 614167..615147 + 981 WP_000921452.1 iron ABC transporter permease -
MPG83_RS02955 (MPG83_02955) 615147..615914 + 768 WP_000242366.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10599.61 Da        Isoelectric Point: 9.7265

>T239273 WP_000928609.1 NZ_CP094140:612291-612563 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T239273 NZ_LR890657:181397-181672 [Serratia marcescens]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGCTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12290.11 Da        Isoelectric Point: 10.1678

>AT239273 WP_001133858.1 NZ_CP094140:611993-612304 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT239273 NZ_LR890657:181200-181397 [Serratia marcescens]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0P915

Antitoxin

Source ID Structure
AlphaFold DB X2IKC6

References