239270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 574798..575422 Replicon chromosome
Accession NZ_CP094139
Organism Helicobacter pylori strain Hpfe036

Toxin (Protein)


Gene name relE Uniprot ID A0A2A6UH71
Locus tag MPG53_RS02800 Protein ID WP_025455067.1
Coordinates 575156..575422 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG53_RS02795 Protein ID WP_245061006.1
Coordinates 574798..575175 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG53_RS02770 (MPG53_02770) 569824..570936 + 1113 WP_245060994.1 hydrogenase formation protein HypD -
MPG53_RS02775 (MPG53_02775) 570887..571529 - 643 Protein_528 helicase DnaB modulator -
MPG53_RS02790 (MPG53_02790) 571909..574134 + 2226 WP_245061004.1 Hop family adhesin BabA -
MPG53_RS02795 (MPG53_02795) 574798..575175 + 378 WP_245061006.1 hypothetical protein Antitoxin
MPG53_RS02800 (MPG53_02800) 575156..575422 + 267 WP_025455067.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MPG53_RS02805 (MPG53_02805) 575528..576052 - 525 WP_128479700.1 acyl-CoA thioesterase -
MPG53_RS02810 (MPG53_02810) 576193..577035 + 843 WP_245061008.1 SDR family oxidoreductase -
MPG53_RS02815 (MPG53_02815) 577028..578008 + 981 WP_029568290.1 iron ABC transporter permease -
MPG53_RS02820 (MPG53_02820) 578008..578775 + 768 WP_088357908.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10303.17 Da        Isoelectric Point: 9.6292

>T239270 WP_025455067.1 NZ_CP094139:575156-575422 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239270 NZ_LR890653:65554-65706 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14654.59 Da        Isoelectric Point: 5.3671

>AT239270 WP_245061006.1 NZ_CP094139:574798-575175 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIEKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GCKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKKALGVETQP

Download         Length: 378 bp

>AT239270 NZ_LR890653:c65504-65442 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6UH71

Antitoxin

Source ID Structure

References