Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2057961..2058447 Replicon chromosome
Accession NC_012891
Organism Streptococcus dysgalactiae subsp. equisimilis GGS 124

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag SDEG_RS10280 Protein ID WP_014407961.1
Coordinates 2057961..2058230 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag SDEG_RS10285 Protein ID WP_014407962.1
Coordinates 2058220..2058447 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDEG_RS10265 2053095..2055368 - 2274 WP_041789159.1 YhgE/Pip domain-containing protein -
SDEG_RS10270 2055503..2056036 + 534 WP_003059589.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
SDEG_RS10275 2056064..2057533 - 1470 Protein_1982 IS1182 family transposase -
SDEG_RS10280 2057961..2058230 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SDEG_RS10285 2058220..2058447 - 228 WP_014407962.1 hypothetical protein Antitoxin
SDEG_RS10290 2058584..2058970 - 387 WP_012767655.1 DUF1492 domain-containing protein -
SDEG_RS10295 2058945..2059307 - 363 WP_012767656.1 DUF1492 domain-containing protein -
SDEG_RS11145 2059578..2059799 - 222 WP_012767657.1 hypothetical protein -
SDEG_RS10305 2059776..2060047 - 272 Protein_1988 hypothetical protein -
SDEG_RS10310 2060037..2060375 - 339 WP_012767659.1 hypothetical protein -
SDEG_RS10315 2060458..2060706 - 249 WP_012767660.1 hypothetical protein -
SDEG_RS10320 2060716..2061501 - 786 WP_012767661.1 hypothetical protein -
SDEG_RS11230 2061590..2061739 - 150 WP_012767662.1 hypothetical protein -
SDEG_RS10325 2061753..2061998 - 246 WP_012767663.1 hypothetical protein -
SDEG_RS10330 2061994..2062320 - 327 Protein_1994 hypothetical protein -
SDEG_RS11235 2062322..2062495 - 174 WP_012767665.1 hypothetical protein -
SDEG_RS10655 2062501..2062674 - 174 WP_003045773.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2035856..2086134 50278
- flank IS/Tn - - 2056033..2057442 1409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T23927 WP_014407961.1 NC_012891:c2058230-2057961 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T23927 NC_012891:c2058230-2057961 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAGCATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGGC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT23927 WP_014407962.1 NC_012891:c2058447-2058220 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT23927 NC_012891:c2058447-2058220 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
ATGGCAATGGTATCATTAAGACTGAACAGTGCAGAGGAAGAGCTTTTCAGAAGCTACGCTACACATACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCGCAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCTATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References