Detailed information of TA system TA239269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 17849..19058
• Replicon: chromosome
• Accession: NZ_CP094139
• Organism: Helicobacter pylori strain Hpfe036

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG53_RS00075
• Protein ID: WP_245060451.1
• Coordinates: 18276..19058 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG53_RS00070
• Protein ID: WP_154489087.1
• Coordinates: 17849..18286 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG53_RS00060 (MPG53_00060)	15480..16005	+	526	Protein_10	hypothetical protein	-
MPG53_RS00065 (MPG53_00065)	15999..17624	+	1626	WP_245061306.1	RNA-directed DNA polymerase	-
MPG53_RS00070 (MPG53_00070)	17849..18286	+	438	WP_154489087.1	Panacea domain-containing protein	Antitoxin
MPG53_RS00075 (MPG53_00075)	18276..19058	+	783	WP_245060451.1	hypothetical protein	Toxin
MPG53_RS00080 (MPG53_00080)	19285..20472	-	1188	WP_000411592.1	transcription termination factor NusA	-
MPG53_RS00085 (MPG53_00085)	20560..21720	-	1161	WP_245060453.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30664.82 Da
• Isoelectric Point: 9.0860

>T239269 WP_245060451.1 NZ_CP094139:18276-19058 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNQEIESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKPIFWFNLMVTILFVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T239269 NZ_LR890653:2252-2533 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCTGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17216.36 Da
• Isoelectric Point: 6.1226

>AT239269 WP_154489087.1 NZ_CP094139:17849-18286 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239269 NZ_LR890653:1986-2255 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA