Detailed information of TA system TA239267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 575773..576397
• Replicon: chromosome
• Accession: NZ_CP094138
• Organism: Helicobacter pylori strain Hpfe037

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG35_RS02760
• Protein ID: WP_245019880.1
• Coordinates: 576131..576397 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG35_RS02755
• Protein ID: WP_245019879.1
• Coordinates: 575773..576150 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG35_RS02735 (MPG35_02735)	571822..572343	-	522	WP_245020006.1	hypothetical protein	-
MPG35_RS02750 (MPG35_02750)	572857..575082	+	2226	WP_245019878.1	Hop family adhesin BabA	-
MPG35_RS02755 (MPG35_02755)	575773..576150	+	378	WP_245019879.1	hypothetical protein	Antitoxin
MPG35_RS02760 (MPG35_02760)	576131..576397	+	267	WP_245019880.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPG35_RS02765 (MPG35_02765)	576501..577025	-	525	WP_001135610.1	acyl-CoA thioesterase	-
MPG35_RS02770 (MPG35_02770)	577165..578013	+	849	WP_245019881.1	SDR family oxidoreductase	-
MPG35_RS02775 (MPG35_02775)	578006..578986	+	981	WP_245019882.1	iron ABC transporter permease	-
MPG35_RS02780 (MPG35_02780)	578986..579753	+	768	WP_245019883.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10275.16 Da
• Isoelectric Point: 9.6041

>T239267 WP_245019880.1 NZ_CP094138:576131-576397 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFKECHIKADILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T239267 NZ_LR890652:c172990-172784 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCTTTGCTGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGAG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14745.69 Da
• Isoelectric Point: 8.4602

>AT239267 WP_245019879.1 NZ_CP094138:575773-576150 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFSLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLFVEDFSSYSDERKRALGVETQS

Nucleotide

• Length: 378 bp

>AT239267 NZ_LR890652:172977-173038 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT