239266

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 575412..576068 Replicon chromosome
Accession NZ_CP094137
Organism Helicobacter pylori strain Hpfe038

Toxin (Protein)


Gene name relE Uniprot ID J0JNR8
Locus tag MPG13_RS02770 Protein ID WP_000916175.1
Coordinates 575412..575678 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F4D6C2
Locus tag MPG13_RS02775 Protein ID WP_001134078.1
Coordinates 575757..576068 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG13_RS02740 (MPG13_02740) 571313..571834 - 522 WP_245083945.1 hypothetical protein -
MPG13_RS02755 (MPG13_02755) 572326..574551 + 2226 WP_245083957.1 Hop family adhesin BabA -
MPG13_RS02760 (MPG13_02760) 574586..574822 - 237 WP_245083959.1 hypothetical protein -
MPG13_RS02765 (MPG13_02765) 575054..575431 + 378 WP_245083961.1 hypothetical protein -
MPG13_RS02770 (MPG13_02770) 575412..575678 + 267 WP_000916175.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MPG13_RS02775 (MPG13_02775) 575757..576068 + 312 WP_001134078.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG13_RS02780 (MPG13_02780) 576055..576325 + 271 Protein_526 type II toxin-antitoxin system YafQ family toxin -
MPG13_RS02785 (MPG13_02785) 576432..576956 - 525 WP_001135603.1 acyl-CoA thioesterase -
MPG13_RS02790 (MPG13_02790) 577096..577938 + 843 WP_245083963.1 SDR family oxidoreductase -
MPG13_RS02795 (MPG13_02795) 577931..578911 + 981 WP_000921452.1 iron ABC transporter permease -
MPG13_RS02800 (MPG13_02800) 578911..579678 + 768 WP_000242367.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10317.20 Da        Isoelectric Point: 9.6292

>T239266 WP_000916175.1 NZ_CP094137:575412-575678 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T239266 NZ_LR890652:c169397-169110 [Escherichia coli]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12278.10 Da        Isoelectric Point: 10.1678

>AT239266 WP_001134078.1 NZ_CP094137:575757-576068 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT239266 NZ_LR890652:c169645-169394 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J0JNR8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L6D4K7

References