Detailed information of TA system TA239265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 575054..575678
• Replicon: chromosome
• Accession: NZ_CP094137
• Organism: Helicobacter pylori strain Hpfe038

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J0JNR8
• Locus tag: MPG13_RS02770
• Protein ID: WP_000916175.1
• Coordinates: 575412..575678 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG13_RS02765
• Protein ID: WP_245083961.1
• Coordinates: 575054..575431 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG13_RS02735 (MPG13_02735)	570250..571362	+	1113	WP_245083943.1	hydrogenase formation protein HypD	-
MPG13_RS02740 (MPG13_02740)	571313..571834	-	522	WP_245083945.1	hypothetical protein	-
MPG13_RS02755 (MPG13_02755)	572326..574551	+	2226	WP_245083957.1	Hop family adhesin BabA	-
MPG13_RS02760 (MPG13_02760)	574586..574822	-	237	WP_245083959.1	hypothetical protein	-
MPG13_RS02765 (MPG13_02765)	575054..575431	+	378	WP_245083961.1	hypothetical protein	Antitoxin
MPG13_RS02770 (MPG13_02770)	575412..575678	+	267	WP_000916175.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MPG13_RS02775 (MPG13_02775)	575757..576068	+	312	WP_001134078.1	type II toxin-antitoxin system antitoxin	-
MPG13_RS02780 (MPG13_02780)	576055..576325	+	271	Protein_526	type II toxin-antitoxin system YafQ family toxin	-
MPG13_RS02785 (MPG13_02785)	576432..576956	-	525	WP_001135603.1	acyl-CoA thioesterase	-
MPG13_RS02790 (MPG13_02790)	577096..577938	+	843	WP_245083963.1	SDR family oxidoreductase	-
MPG13_RS02795 (MPG13_02795)	577931..578911	+	981	WP_000921452.1	iron ABC transporter permease	-
MPG13_RS02800 (MPG13_02800)	578911..579678	+	768	WP_000242367.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10317.20 Da
• Isoelectric Point: 9.6292

>T239265 WP_000916175.1 NZ_CP094137:575412-575678 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T239265 NZ_LR890652:c100324-100142 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14552.53 Da
• Isoelectric Point: 9.0038

>AT239265 WP_245083961.1 NZ_CP094137:575054-575431 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDGKRDCCL
GRKIPNIETQQAMRDALNKETDLIVEDFSSYSDERKKALGVETQS

Nucleotide

• Length: 378 bp

>AT239265 NZ_LR890652:c100518-100321 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: J0JNR8