Detailed information of TA system TA239262

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 20332..21541
• Replicon: chromosome
• Accession: NZ_CP094134
• Organism: Helicobacter pylori strain Hpfe048

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG50_RS00075
• Protein ID: WP_245032218.1
• Coordinates: 20759..21541 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG50_RS00070
• Protein ID: WP_245032216.1
• Coordinates: 20332..20769 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG50_RS00060 (MPG50_00060)	17932..18522	+	591	WP_245032214.1	hypothetical protein	-
MPG50_RS00065 (MPG50_00065)	18485..20108	+	1624	Protein_11	RNA-directed DNA polymerase	-
MPG50_RS00070 (MPG50_00070)	20332..20769	+	438	WP_245032216.1	Panacea domain-containing protein	Antitoxin
MPG50_RS00075 (MPG50_00075)	20759..21541	+	783	WP_245032218.1	hypothetical protein	Toxin
MPG50_RS00080 (MPG50_00080)	21766..22953	-	1188	WP_245032220.1	transcription termination factor NusA	-
MPG50_RS00085 (MPG50_00085)	23041..24201	-	1161	WP_245032222.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30590.83 Da
• Isoelectric Point: 9.5823

>T239262 WP_245032218.1 NZ_CP094134:20759-21541 [Helicobacter pylori]
MEIKEENKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKNVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYRLFSFLSKISLSEEKKDKQENFFKKPIFWFNLMVIILFVIGFV
GERIDGQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T239262 NZ_LR890652:c33953-33648 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17221.30 Da
• Isoelectric Point: 5.3873

>AT239262 WP_245032216.1 NZ_CP094134:20332-20769 [Helicobacter pylori]
VVNALELAKYILKHSNKELSNLELQKTLYFAELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQDLREDELEIINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239262 NZ_LR890652:c34173-33955 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA