Detailed information of TA system TA239260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 566930..567500
• Replicon: chromosome
• Accession: NZ_CP094133
• Organism: Helicobacter pylori strain Hpfe049

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG21_RS02750
• Protein ID: WP_180589475.1
• Coordinates: 567228..567500 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0M0MSJ1
• Locus tag: MPG21_RS02745
• Protein ID: WP_001133857.1
• Coordinates: 566930..567241 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG21_RS02720 (MPG21_02720)	562131..563243	+	1113	WP_245025857.1	hydrogenase formation protein HypD	-
MPG21_RS02725 (MPG21_02725)	563194..563715	-	522	WP_245025858.1	hypothetical protein	-
MPG21_RS02740 (MPG21_02740)	564223..566454	+	2232	WP_245025859.1	Hop family adhesin BabA	-
MPG21_RS02745 (MPG21_02745)	566930..567241	+	312	WP_001133857.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPG21_RS02750 (MPG21_02750)	567228..567500	+	273	WP_180589475.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
MPG21_RS02755 (MPG21_02755)	567606..568130	-	525	WP_120845779.1	acyl-CoA thioesterase	-
MPG21_RS02760 (MPG21_02760)	568273..569115	+	843	WP_245025860.1	SDR family oxidoreductase	-
MPG21_RS02765 (MPG21_02765)	569108..570088	+	981	WP_000921482.1	iron ABC transporter permease	-
MPG21_RS02770 (MPG21_02770)	570088..570855	+	768	WP_120801348.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10521.59 Da
• Isoelectric Point: 9.9378

>T239260 WP_180589475.1 NZ_CP094133:567228-567500 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLAPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLLL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239260 NZ_LR890651:c4739734-4739423 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12331.16 Da
• Isoelectric Point: 10.1678

>AT239260 WP_001133857.1 NZ_CP094133:566930-567241 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239260 NZ_LR890651:c4739422-4739132 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A0M0MSJ1