Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 262314..262926 Replicon chromosome
Accession NC_012891
Organism Streptococcus dysgalactiae subsp. equisimilis GGS 124

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag SDEG_RS01410 Protein ID WP_000384858.1
Coordinates 262314..262649 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag SDEG_RS01415 Protein ID WP_000255538.1
Coordinates 262639..262926 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDEG_RS01385 257511..258140 + 630 WP_012766542.1 hypothetical protein -
SDEG_RS01390 258454..259329 + 876 WP_000770113.1 hypothetical protein -
SDEG_RS01395 259365..259799 + 435 WP_001220479.1 hypothetical protein -
SDEG_RS01400 260115..261371 + 1257 WP_000122832.1 plasmid recombination protein -
SDEG_RS01405 261539..262009 + 471 WP_000130119.1 hypothetical protein -
SDEG_RS01410 262314..262649 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SDEG_RS01415 262639..262926 - 288 WP_000255538.1 hypothetical protein Antitoxin
SDEG_RS01420 263330..263941 - 612 WP_171842254.1 tyrosine-type recombinase/integrase -
SDEG_RS10680 264073..264933 - 861 Protein_247 IS982 family transposase -
SDEG_RS01435 265019..266161 + 1143 Protein_248 lanthionine synthetase C family protein -
SDEG_RS01440 266191..267456 + 1266 WP_012766546.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T23926 WP_000384858.1 NC_012891:c262649-262314 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T23926 NC_012891:c262649-262314 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT23926 WP_000255538.1 NC_012891:c262926-262639 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT23926 NC_012891:c262926-262639 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References