Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 578208..578778 Replicon chromosome
Accession NZ_CP094132
Organism Helicobacter pylori strain Hpfe051

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG57_RS02820 Protein ID WP_048944940.1
Coordinates 578506..578778 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG57_RS02815 Protein ID WP_245081524.1
Coordinates 578208..578519 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG57_RS02775 (MPG57_02775) 573382..573903 - 522 WP_245081513.1 hypothetical protein -
MPG57_RS02790 (MPG57_02790) 574416..576650 + 2235 WP_245081522.1 Hop family adhesin BabA -
MPG57_RS02795 (MPG57_02795) 577078..577245 + 168 WP_245081863.1 hypothetical protein -
MPG57_RS02800 (MPG57_02800) 577315..577428 + 114 Protein_530 MerR family DNA-binding transcriptional regulator -
MPG57_RS02805 (MPG57_02805) 577428..577888 + 461 Protein_531 RNA-guided endonuclease TnpB family protein -
MPG57_RS02810 (MPG57_02810) 577940..578132 + 193 Protein_532 hypothetical protein -
MPG57_RS02815 (MPG57_02815) 578208..578519 + 312 WP_245081524.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG57_RS02820 (MPG57_02820) 578506..578778 + 273 WP_048944940.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
MPG57_RS02825 (MPG57_02825) 578834..579358 - 525 WP_180609742.1 acyl-CoA thioesterase -
MPG57_RS02830 (MPG57_02830) 579499..580341 + 843 WP_154427235.1 SDR family oxidoreductase -
MPG57_RS02835 (MPG57_02835) 580334..581314 + 981 WP_000921482.1 iron ABC transporter permease -
MPG57_RS02840 (MPG57_02840) 581314..582081 + 768 WP_245081526.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 577315..577467 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10629.64 Da        Isoelectric Point: 9.7265

>T239258 WP_048944940.1 NZ_CP094132:578506-578778 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGTLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T239258 NZ_LR890651:3901878-3902156 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12371.23 Da        Isoelectric Point: 10.1909

>AT239258 WP_245081524.1 NZ_CP094132:578208-578519 [Helicobacter pylori]
MPNSPIKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARARDTKNH
LCFKNIEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT239258 NZ_LR890651:3901615-3901875 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References