Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 100980..101604 Replicon chromosome
Accession NZ_CP094130
Organism Helicobacter pylori strain Hpfe053

Toxin (Protein)


Gene name relE Uniprot ID A0A1Q2PIC7
Locus tag MPF99_RS00500 Protein ID WP_000916176.1
Coordinates 100980..101246 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPF99_RS00505 Protein ID WP_245058905.1
Coordinates 101227..101604 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF99_RS00480 (MPF99_00480) 97649..98416 - 768 WP_121018883.1 ABC transporter ATP-binding protein -
MPF99_RS00485 (MPF99_00485) 98416..99396 - 981 WP_000921452.1 iron ABC transporter permease -
MPF99_RS00490 (MPF99_00490) 99389..100231 - 843 WP_245058903.1 SDR family oxidoreductase -
MPF99_RS00495 (MPF99_00495) 100372..100896 + 525 WP_001120211.1 acyl-CoA thioesterase -
MPF99_RS00500 (MPF99_00500) 100980..101246 - 267 WP_000916176.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MPF99_RS00505 (MPF99_00505) 101227..101604 - 378 WP_245058905.1 hypothetical protein Antitoxin
MPF99_RS00510 (MPF99_00510) 101955..104189 - 2235 WP_245058910.1 Hop family adhesin BabA -
MPF99_RS00525 (MPF99_00525) 104584..105210 + 627 WP_245058912.1 helicase DnaB modulator -
MPF99_RS00530 (MPF99_00530) 105161..106273 - 1113 WP_245058913.1 hydrogenase formation protein HypD -
MPF99_RS00535 (MPF99_00535) 106292..106528 - 237 WP_000335473.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10245.13 Da        Isoelectric Point: 9.9517

>T239256 WP_000916176.1 NZ_CP094130:c101246-100980 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T239256 NZ_LR890651:3643969-3644187 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14711.54 Da        Isoelectric Point: 6.9596

>AT239256 WP_245058905.1 NZ_CP094130:c101604-101227 [Helicobacter pylori]
MPNSSAKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDNKRDCCF
GHETPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT239256 NZ_LR890651:3643569-3643943 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q2PIC7

Antitoxin

Source ID Structure

References