Detailed information of TA system TA239253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 20284..21493
• Replicon: chromosome
• Accession: NZ_CP094128
• Organism: Helicobacter pylori strain Hpfe055

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG79_RS00075
• Protein ID: WP_245107484.1
• Coordinates: 20711..21493 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A293SJW7
• Locus tag: MPG79_RS00070
• Protein ID: WP_025288523.1
• Coordinates: 20284..20721 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG79_RS00060 (MPG79_00060)	18447..18734	+	288	WP_245107905.1	hypothetical protein	-
MPG79_RS00065 (MPG79_00065)	18867..20060	+	1194	WP_245107483.1	RNA-directed DNA polymerase	-
MPG79_RS00070 (MPG79_00070)	20284..20721	+	438	WP_025288523.1	Panacea domain-containing protein	Antitoxin
MPG79_RS00075 (MPG79_00075)	20711..21493	+	783	WP_245107484.1	hypothetical protein	Toxin
MPG79_RS00080 (MPG79_00080)	21722..22909	-	1188	WP_245107485.1	transcription termination factor NusA	-
MPG79_RS00085 (MPG79_00085)	22997..24157	-	1161	WP_245107486.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30492.67 Da
• Isoelectric Point: 7.8445

>T239253 WP_245107484.1 NZ_CP094128:20711-21493 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKTKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNRQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWLNLMVTIL
FVIGFFGELHIIQRLVSKYL

Nucleotide

• Length: 783 bp

>T239253 NZ_LR890651:2474179-2475009 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGATCGTTATGATTTTATGAAAT
TCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAGGCTGGCGGCAGT
TATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACATCAGCGATCTCAA
ACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATTTTTTGGCGACAG
CAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCGGCAGCACTGGAT
AACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTTGAGGTTGCATGG
ACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17299.43 Da
• Isoelectric Point: 6.4976

>AT239253 WP_025288523.1 NZ_CP094128:20284-20721 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239253 NZ_LR890651:2473913-2474179 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A293SJW7