Detailed information of TA system TA239251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 633633..634203
• Replicon: chromosome
• Accession: NZ_CP094122
• Organism: Helicobacter pylori strain Hpfe058

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG73_RS03070
• Protein ID: WP_048944940.1
• Coordinates: 633931..634203 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2IKC6
• Locus tag: MPG73_RS03065
• Protein ID: WP_001133858.1
• Coordinates: 633633..633944 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG73_RS03035 (MPG73_03035)	628651..628887	+	237	WP_000335459.1	HypC/HybG/HupF family hydrogenase formation chaperone	-
MPG73_RS03040 (MPG73_03040)	628906..630018	+	1113	WP_245057662.1	hydrogenase formation protein HypD	-
MPG73_RS03045 (MPG73_03045)	629969..630541	-	573	WP_245057873.1	helicase DnaB modulator	-
MPG73_RS03060 (MPG73_03060)	631009..633234	+	2226	WP_245057672.1	Hop family adhesin BabA	-
MPG73_RS07865	633256..633381	-	126	WP_280636173.1	hypothetical protein	-
MPG73_RS03065 (MPG73_03065)	633633..633944	+	312	WP_001133858.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPG73_RS03070 (MPG73_03070)	633931..634203	+	273	WP_048944940.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
MPG73_RS03075 (MPG73_03075)	634309..634833	-	525	WP_180606023.1	acyl-CoA thioesterase	-
MPG73_RS03080 (MPG73_03080)	634974..635816	+	843	WP_245057674.1	SDR family oxidoreductase	-
MPG73_RS03085 (MPG73_03085)	635809..636789	+	981	WP_000921458.1	iron chelate uptake ABC transporter family permease subunit	-
MPG73_RS03090 (MPG73_03090)	636789..637556	+	768	WP_000242366.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10629.64 Da
• Isoelectric Point: 9.7265

>T239251 WP_048944940.1 NZ_CP094122:633931-634203 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGTLKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239251 NZ_LR890651:1909005-1909259 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12290.11 Da
• Isoelectric Point: 10.1678

>AT239251 WP_001133858.1 NZ_CP094122:633633-633944 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239251 NZ_LR890651:1908757-1909008 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: X2IKC6