Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 20287..21481 Replicon chromosome
Accession NZ_CP094122
Organism Helicobacter pylori strain Hpfe058

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPG73_RS00090 Protein ID WP_245057085.1
Coordinates 20714..21481 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPG73_RS00085 Protein ID WP_245057083.1
Coordinates 20287..20724 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG73_RS00065 (MPG73_00065) 17905..18433 + 529 Protein_11 hypothetical protein -
MPG73_RS00070 (MPG73_00070) 18536..18871 + 336 WP_245057077.1 hypothetical protein -
MPG73_RS00075 (MPG73_00075) 18868..19380 + 513 WP_245057079.1 RNA-directed DNA polymerase -
MPG73_RS00080 (MPG73_00080) 19408..20061 + 654 WP_245057081.1 hypothetical protein -
MPG73_RS00085 (MPG73_00085) 20287..20724 + 438 WP_245057083.1 Panacea domain-containing protein Antitoxin
MPG73_RS00090 (MPG73_00090) 20714..21481 + 768 WP_245057085.1 hypothetical protein Toxin
MPG73_RS00095 (MPG73_00095) 21711..22898 - 1188 WP_245057087.1 transcription termination factor NusA -
MPG73_RS00100 (MPG73_00100) 22986..24146 - 1161 WP_245057089.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29930.13 Da        Isoelectric Point: 8.3803

>T239249 WP_245057085.1 NZ_CP094122:20714-21481 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIKLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKLIFWFNLMVTILFVIGFVG
ELHINIIQRLISKYL

Download         Length: 768 bp

>T239249 NZ_LR890651:1393220-1393618 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17235.34 Da        Isoelectric Point: 5.7911

>AT239249 WP_245057083.1 NZ_CP094122:20287-20724 [Helicobacter pylori]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGASSIDKPKEETL
SQSLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239249 NZ_LR890651:1392993-1393220 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References