Detailed information of TA system TA239248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 580135..580792
• Replicon: chromosome
• Accession: NZ_CP094121
• Organism: Helicobacter pylori strain Hpfe059

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: -
• Locus tag: MPG25_RS02785
• Protein ID: WP_245019014.1
• Coordinates: 580508..580792 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG25_RS02780
• Protein ID: WP_245019013.1
• Coordinates: 580135..580527 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG25_RS02760 (576132)	576132..576761	-	630	WP_245019011.1	helicase DnaB modulator	-
MPG25_RS02775 (577395)	577395..579617	+	2223	WP_245019012.1	outer membrane beta-barrel protein	-
MPG25_RS02780 (580135)	580135..580527	+	393	WP_245019013.1	hypothetical protein	Antitoxin
MPG25_RS02785 (580508)	580508..580792	+	285	WP_245019014.1	endoribonuclease VapD	Toxin
MPG25_RS02790 (580966)	580966..581490	-	525	WP_001135602.1	acyl-CoA thioesterase	-
MPG25_RS02795 (581630)	581630..582478	+	849	WP_245019015.1	SDR family oxidoreductase	-
MPG25_RS02800 (582471)	582471..583451	+	981	WP_245019016.1	iron ABC transporter permease	-
MPG25_RS02805 (583451)	583451..584218	+	768	WP_245019017.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11248.84 Da
• Isoelectric Point: 4.8896

>T239248 WP_245019014.1 NZ_CP094121:580508-580792 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKF

Nucleotide

• Length: 285 bp

>T239248 NZ_LR890651:984639-984974 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15166.08 Da
• Isoelectric Point: 5.9488

>AT239248 WP_245019013.1 NZ_CP094121:580135-580527 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNLETQQAMRDALNGVNLTQIDSLNDLTNELKRENGKGFENVCFSV

Nucleotide

• Length: 393 bp

>AT239248 NZ_LR890651:984391-984639 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA