Detailed information of TA system TA239244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1105352..1105976
• Replicon: chromosome
• Accession: NZ_CP094119
• Organism: Helicobacter pylori strain Hpfe064

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG78_RS05340
• Protein ID: WP_075645685.1
• Coordinates: 1105352..1105618 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG78_RS05345
• Protein ID: WP_245039694.1
• Coordinates: 1105599..1105976 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG78_RS05320 (MPG78_05320)	1102026..1102793	-	768	WP_000242367.1	ABC transporter ATP-binding protein	-
MPG78_RS05325 (MPG78_05325)	1102793..1103773	-	981	WP_245039690.1	iron ABC transporter permease	-
MPG78_RS05330 (MPG78_05330)	1103766..1104608	-	843	WP_245039692.1	SDR family oxidoreductase	-
MPG78_RS05335 (MPG78_05335)	1104748..1105272	+	525	WP_001135602.1	acyl-CoA thioesterase	-
MPG78_RS05340 (MPG78_05340)	1105352..1105618	-	267	WP_075645685.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MPG78_RS05345 (MPG78_05345)	1105599..1105976	-	378	WP_245039694.1	hypothetical protein	Antitoxin
MPG78_RS05350 (MPG78_05350)	1106613..1108817	-	2205	WP_245039699.1	Hop family adhesin BabA	-
MPG78_RS05365 (MPG78_05365)	1109317..1109838	+	522	WP_245039700.1	hypothetical protein	-
MPG78_RS05370 (MPG78_05370)	1109789..1110901	-	1113	WP_245039702.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10304.11 Da
• Isoelectric Point: 8.0602

>T239244 WP_075645685.1 NZ_CP094119:c1105618-1105352 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T239244 NZ_LR890649:c82033-81563 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGAATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAATTGATCCAAAGCGCAAATATGGAT
GAATTACCGGCCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCTCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACTCTGATTTTT
ACGGGATCGTGCAGATGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14662.73 Da
• Isoelectric Point: 9.6852

>AT239244 WP_245039694.1 NZ_CP094119:c1105976-1105599 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFSLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFGDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT239244 NZ_LR890649:c82473-82030 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATAG
CGTAGCGCTGCTGGGTCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AAAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGACTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGATAAGGAAGCCGCACTGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATAGCATCCGAGACGGGAGCATATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA