Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 602966..603590 Replicon chromosome
Accession NZ_CP094113
Organism Helicobacter pylori strain Hpfe069

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG48_RS02900 Protein ID WP_245065742.1
Coordinates 603324..603590 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG48_RS02895 Protein ID WP_245065739.1
Coordinates 602966..603343 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG48_RS02870 (MPG48_02870) 598028..599140 + 1113 WP_245065736.1 hydrogenase formation protein HypD -
MPG48_RS02875 (MPG48_02875) 599091..599663 - 573 WP_245065954.1 helicase DnaB modulator -
MPG48_RS02890 (MPG48_02890) 600134..602368 + 2235 WP_245065738.1 Hop family adhesin BabA -
MPG48_RS02895 (MPG48_02895) 602966..603343 + 378 WP_245065739.1 hypothetical protein Antitoxin
MPG48_RS02900 (MPG48_02900) 603324..603590 + 267 WP_245065742.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG48_RS02905 (MPG48_02905) 603693..604217 - 525 WP_001135603.1 acyl-CoA thioesterase -
MPG48_RS02910 (MPG48_02910) 604357..605199 + 843 WP_245065744.1 SDR family oxidoreductase -
MPG48_RS02915 (MPG48_02915) 605192..606172 + 981 WP_000921452.1 iron ABC transporter permease -
MPG48_RS02920 (MPG48_02920) 606172..606939 + 768 WP_000242368.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10330.15 Da        Isoelectric Point: 8.0602

>T239241 WP_245065742.1 NZ_CP094113:603324-603590 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239241 NZ_LR890648:c5266979-5266596 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14640.59 Da        Isoelectric Point: 8.4602

>AT239241 WP_245065739.1 NZ_CP094113:602966-603343 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFGDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQS

Download         Length: 378 bp

>AT239241 NZ_LR890648:c5267221-5266979 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References