Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 602958..603582 Replicon chromosome
Accession NZ_CP094111
Organism Helicobacter pylori strain Hpfe070

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG22_RS02900 Protein ID WP_245065742.1
Coordinates 603316..603582 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG22_RS02895 Protein ID WP_245065739.1
Coordinates 602958..603335 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG22_RS02870 (MPG22_02870) 598021..599133 + 1113 WP_245065736.1 hydrogenase formation protein HypD -
MPG22_RS02875 (MPG22_02875) 599084..599656 - 573 WP_245065954.1 helicase DnaB modulator -
MPG22_RS02890 (MPG22_02890) 600128..602362 + 2235 WP_245065738.1 Hop family adhesin BabA -
MPG22_RS02895 (MPG22_02895) 602958..603335 + 378 WP_245065739.1 hypothetical protein Antitoxin
MPG22_RS02900 (MPG22_02900) 603316..603582 + 267 WP_245065742.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG22_RS02905 (MPG22_02905) 603685..604209 - 525 WP_001135603.1 acyl-CoA thioesterase -
MPG22_RS02910 (MPG22_02910) 604349..605191 + 843 WP_245065744.1 SDR family oxidoreductase -
MPG22_RS02915 (MPG22_02915) 605184..606164 + 981 WP_000921452.1 iron ABC transporter permease -
MPG22_RS02920 (MPG22_02920) 606164..606931 + 768 WP_000242368.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10330.15 Da        Isoelectric Point: 8.0602

>T239239 WP_245065742.1 NZ_CP094111:603316-603582 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239239 NZ_LR890648:c4787742-4787458 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14640.59 Da        Isoelectric Point: 8.4602

>AT239239 WP_245065739.1 NZ_CP094111:602958-603335 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFGDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQS

Download         Length: 378 bp

>AT239239 NZ_LR890648:c4787974-4787732 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References