239237

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 621154..621778 Replicon chromosome
Accession NZ_CP094110
Organism Helicobacter pylori strain Hpfe071

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG24_RS02940 Protein ID WP_140497734.1
Coordinates 621512..621778 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG24_RS02935 Protein ID WP_245104717.1
Coordinates 621154..621531 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG24_RS02910 (MPG24_02910) 616386..617498 + 1113 WP_245104714.1 hydrogenase formation protein HypD -
MPG24_RS02915 (MPG24_02915) 617449..618021 - 573 WP_245104944.1 helicase DnaB modulator -
MPG24_RS02930 (MPG24_02930) 618490..620712 + 2223 WP_245104715.1 Hop family adhesin BabA -
MPG24_RS02935 (MPG24_02935) 621154..621531 + 378 WP_245104717.1 hypothetical protein Antitoxin
MPG24_RS02940 (MPG24_02940) 621512..621778 + 267 WP_140497734.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG24_RS02945 (MPG24_02945) 621853..622377 - 525 WP_001120211.1 acyl-CoA thioesterase -
MPG24_RS02950 (MPG24_02950) 622518..623360 + 843 WP_245104719.1 SDR family oxidoreductase -
MPG24_RS02955 (MPG24_02955) 623353..624333 + 981 WP_245104721.1 iron ABC transporter permease -
MPG24_RS02960 (MPG24_02960) 624333..625100 + 768 WP_120824486.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10318.18 Da        Isoelectric Point: 9.0027

>T239237 WP_140497734.1 NZ_CP094110:621512-621778 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239237 NZ_LR890648:4220817-4221185 [Klebsiella pneumoniae]
ATGAAAAATCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCATCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGTGATGAAGCCGTTATACAGGAACATATTG
ATGCCGGTATCACTCTGGCTAATGCTGTTAACTTTCTGGTGGAGAAGTATGAGTTAGTCCGTATCGATCGCTGTGGATTT
TCCTCACAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCATGCCAGGAAAGCGTGCGGGCTGATGAGCCGGTA
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGATATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14767.78 Da        Isoelectric Point: 8.4692

>AT239237 WP_245104717.1 NZ_CP094110:621154-621531 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLVNLIHQLERKIKKMQNDRVSFKERMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT239237 NZ_LR890648:4220479-4220796 [Klebsiella pneumoniae]
ATGAGCAACCCCACATGGGGCCTGCTGCGGGATATCACGCCGTGCCTAGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GTACTATCTGGTTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAATCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGCTGACCATTGGTGAAATGAATCCCCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCTCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References