239233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 607124..607748 Replicon chromosome
Accession NZ_CP094106
Organism Helicobacter pylori strain Hpfe075

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPF92_RS02880 Protein ID WP_154483558.1
Coordinates 607482..607748 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPF92_RS02875 Protein ID WP_245024202.1
Coordinates 607124..607501 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF92_RS02845 (MPF92_02845) 602219..602455 + 237 WP_000335476.1 HypC/HybG/HupF family hydrogenase formation chaperone -
MPF92_RS02850 (MPF92_02850) 602474..603586 + 1113 WP_245024197.1 hydrogenase formation protein HypD -
MPF92_RS02855 (MPF92_02855) 603537..604183 - 647 Protein_544 helicase DnaB modulator -
MPF92_RS02870 (MPF92_02870) 604603..606828 + 2226 WP_245024199.1 Hop family adhesin BabA -
MPF92_RS02875 (MPF92_02875) 607124..607501 + 378 WP_245024202.1 hypothetical protein Antitoxin
MPF92_RS02880 (MPF92_02880) 607482..607748 + 267 WP_154483558.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPF92_RS02885 (MPF92_02885) 607886..608410 - 525 WP_096469270.1 acyl-CoA thioesterase -
MPF92_RS02890 (MPF92_02890) 608550..609398 + 849 WP_245024204.1 SDR family oxidoreductase -
MPF92_RS02895 (MPF92_02895) 609391..610371 + 981 WP_245024205.1 iron ABC transporter permease -
MPF92_RS02900 (MPF92_02900) 610371..611138 + 768 WP_000242365.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10231.11 Da        Isoelectric Point: 9.9517

>T239233 WP_154483558.1 NZ_CP094106:607482-607748 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T239233 NZ_LR890648:788888-789298 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14648.66 Da        Isoelectric Point: 9.0037

>AT239233 WP_245024202.1 NZ_CP094106:607124-607501 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDDKRDCCL
GRKIPNLETQQAMREALNKETDLIVDDFSSYSDERKKALGVETQP

Download         Length: 378 bp

>AT239233 NZ_LR890648:788641-788907 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References