Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3990809..3991335 Replicon chromosome
Accession NC_012880
Organism Dickeya dadantii Ech703

Toxin (Protein)


Gene name ccdB Uniprot ID C6C381
Locus tag DD703_RS17005 Protein ID WP_015855077.1
Coordinates 3991030..3991335 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID C6C380
Locus tag DD703_RS17000 Protein ID WP_015855076.1
Coordinates 3990809..3991027 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD703_RS16970 3985896..3986471 + 576 WP_015855072.1 transcriptional regulator -
DD703_RS16980 3987035..3988309 + 1275 WP_015855073.1 integrase arm-type DNA-binding domain-containing protein -
DD703_RS16985 3988450..3988638 - 189 WP_033111580.1 hypothetical protein -
DD703_RS16990 3988761..3989111 + 351 WP_015855074.1 hypothetical protein -
DD703_RS16995 3990007..3990750 + 744 WP_015855075.1 hypothetical protein -
DD703_RS17000 3990809..3991027 + 219 WP_015855076.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DD703_RS17005 3991030..3991335 + 306 WP_015855077.1 type II toxin-antitoxin system toxin CcdB Toxin
DD703_RS17010 3991477..3992475 - 999 WP_015855078.1 reverse transcriptase family protein -
DD703_RS17015 3992646..3993383 - 738 WP_015855079.1 hypothetical protein -
DD703_RS17020 3993373..3993900 - 528 WP_015855080.1 hypothetical protein -
DD703_RS17025 3994531..3994872 - 342 WP_023638471.1 hypothetical protein -
DD703_RS17030 3994882..3995148 - 267 WP_015855082.1 hypothetical protein -
DD703_RS17035 3995729..3995971 - 243 WP_023638472.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3986858..3995656 8798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11746.64 Da        Isoelectric Point: 5.1200

>T23923 WP_015855077.1 NC_012880:3991030-3991335 [Dickeya paradisiaca Ech703]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGETI
ANLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T23923 NC_012880:3991030-3991335 [Dickeya paradisiaca Ech703]
ATGCAATTCATTGTTTATCAATACAAACGCGCCAGTCACTACAAAATGTTTGTCGATGTACAAAGCGATATTGTCGAGAC
ACCCAAGCGGCGCATGGTCATTCCACTTATCGAAGCACATCACCTGTCTGAGAAAGTGAATAAAACGCTGTTCCCTCTGA
TCCGCATCGACGGCGAAGATTATCGGCTAATGACTACTGAACTATCGAGCGTTCCCGTTGAAGTCATTGGTGAAACCATC
GCGAATCTTGGCGACTACGCGGATGAGATCAAGGATGCGATTAATCTTATGTTTTGGGGGATATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8178.13 Da        Isoelectric Point: 7.0135

>AT23923 WP_015855076.1 NC_012880:3990809-3991027 [Dickeya paradisiaca Ech703]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT23923 NC_012880:3990809-3991027 [Dickeya paradisiaca Ech703]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTAAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGACGCCATTGGCAAAGAAGCCCGCCGCATAAAGGCTGAAGAGTGGAAGAAAGAAAACCGCGAAGGGATGGAGG
AAGTCGCCCGATTTATCGCACAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C6C381

Antitoxin

Source ID Structure
AlphaFold DB A0A250BG46

References