239227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 578417..579041 Replicon chromosome
Accession NZ_CP094099
Organism Helicobacter pylori strain Hpfe080

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG36_RS02790 Protein ID WP_180512150.1
Coordinates 578775..579041 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG36_RS02785 Protein ID WP_220944163.1
Coordinates 578417..578788 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG36_RS02755 (MPG36_02755) 573445..573681 + 237 WP_000335472.1 HypC/HybG/HupF family hydrogenase formation chaperone -
MPG36_RS02760 (MPG36_02760) 573709..574821 + 1113 WP_245017308.1 hydrogenase formation protein HypD -
MPG36_RS02765 (MPG36_02765) 574772..575389 - 618 WP_245017309.1 helicase DnaB modulator -
MPG36_RS02780 (MPG36_02780) 575784..578018 + 2235 WP_245017310.1 Hop family adhesin BabA -
MPG36_RS02785 (MPG36_02785) 578417..578788 + 372 WP_220944163.1 hypothetical protein Antitoxin
MPG36_RS02790 (MPG36_02790) 578775..579041 + 267 WP_180512150.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG36_RS02795 (MPG36_02795) 579148..579672 - 525 WP_058338129.1 acyl-CoA thioesterase -
MPG36_RS02800 (MPG36_02800) 579813..580655 + 843 WP_245017311.1 SDR family oxidoreductase -
MPG36_RS02805 (MPG36_02805) 580648..581628 + 981 WP_000921452.1 iron ABC transporter permease -
MPG36_RS02810 (MPG36_02810) 581628..582395 + 768 WP_121018883.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10466.50 Da        Isoelectric Point: 10.0164

>T239227 WP_180512150.1 NZ_CP094099:578775-579041 [Helicobacter pylori]
MLKIKHHILYKKDFKKLIKNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T239227 NZ_LR890643:c4656178-4655894 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14443.36 Da        Isoelectric Point: 7.7809

>AT239227 WP_220944163.1 NZ_CP094099:578417-578788 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNGENLETIEDFSAWANEVKKEVNAEN

Download         Length: 372 bp

>AT239227 NZ_LR890643:c4656410-4656168 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References