Detailed information of TA system TA239226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1008923..1009547
• Replicon: chromosome
• Accession: NZ_CP094098
• Organism: Helicobacter pylori strain Hpfe081

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG76_RS04745
• Protein ID: WP_096465015.1
• Coordinates: 1008923..1009189 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG76_RS04750
• Protein ID: WP_245037886.1
• Coordinates: 1009170..1009547 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG76_RS04725 (MPG76_04725)	1005566..1006333	-	768	WP_000242365.1	ABC transporter ATP-binding protein	-
MPG76_RS04730 (MPG76_04730)	1006333..1007313	-	981	WP_000921452.1	iron ABC transporter permease	-
MPG76_RS04735 (MPG76_04735)	1007306..1008148	-	843	WP_180608288.1	SDR family oxidoreductase	-
MPG76_RS04740 (MPG76_04740)	1008289..1008813	+	525	WP_245037884.1	acyl-CoA thioesterase	-
MPG76_RS04745 (MPG76_04745)	1008923..1009189	-	267	WP_096465015.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPG76_RS04750 (MPG76_04750)	1009170..1009547	-	378	WP_245037886.1	hypothetical protein	Antitoxin
MPG76_RS04755 (MPG76_04755)	1010302..1012536	-	2235	WP_245037894.1	Hop family adhesin BabA	-
MPG76_RS04770 (MPG76_04770)	1012902..1013554	+	653	Protein_942	helicase DnaB modulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10317.16 Da
• Isoelectric Point: 9.6561

>T239226 WP_096465015.1 NZ_CP094098:c1009189-1008923 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVRDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T239226 NZ_LR890643:c4575030-4574710 [Klebsiella pneumoniae]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGAACACCATTACGGCCTGACACTTAACGACACGCCATTTCAAGACGACGAGGCCATCCAAGAGCATATTG
AAGCTGGTATTACACTTGCTGATGCAGTGAATTTCCTGGTGGAACGCTATGAACTGGTACGCACTGACCGTAAGGGATTC
ACTTGGCAAGATCAAACACCATTCCTGACCGCCACCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATAAATACTTG
A

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14706.69 Da
• Isoelectric Point: 8.4575

>AT239226 WP_245037886.1 NZ_CP094098:c1009547-1009170 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMREALNKETDLIVDDFSSYSDERKKALGVETQP

Nucleotide

• Length: 378 bp

>AT239226 NZ_LR890643:c4575387-4575064 [Klebsiella pneumoniae]
ATGCCATTCACACTATCCCATGGATGGGGGATACAAAGCGATATAACCCAACGATTTGGCGCAAGATTAGTTCAGGAAGG
CAACCGGCTGCATTACCTGGCTGACAGGGCTAGTTTGACGGGAAGCTTTAGCCCAGAGCAGCTACAAAGCCTGGAAAATG
CTTTCCCACTGTTTATAGAGCAGTTAGGAAATATGTTGCGTTCCGGTGAGCTAAATCCACAGCAGCAACATCAGATGACC
ATTCAGCTTACAGGTCTAACTTGTATAGCTGATACCCTTAGTAGCTGGGGCTACGTTTACCTCACTGTTTATCCCGCCCA
ATAA