Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 573758..574328 Replicon chromosome
Accession NZ_CP094096
Organism Helicobacter pylori strain Hpfe082

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG69_RS02765 Protein ID WP_245056432.1
Coordinates 574056..574328 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG69_RS02760 Protein ID WP_245056431.1
Coordinates 573758..574069 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG69_RS02735 (MPG69_02735) 568784..569896 + 1113 WP_245056411.1 hydrogenase formation protein HypD -
MPG69_RS02740 (MPG69_02740) 569847..570368 - 522 WP_245056413.1 hypothetical protein -
MPG69_RS02755 (MPG69_02755) 570885..573110 + 2226 WP_245056430.1 Hop family adhesin BabA -
MPG69_RS02760 (MPG69_02760) 573758..574069 + 312 WP_245056431.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG69_RS02765 (MPG69_02765) 574056..574328 + 273 WP_245056432.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG69_RS02770 (MPG69_02770) 574432..574956 - 525 WP_058060478.1 acyl-CoA thioesterase -
MPG69_RS02775 (MPG69_02775) 575100..575942 + 843 WP_245056433.1 SDR family oxidoreductase -
MPG69_RS02780 (MPG69_02780) 575935..576915 + 981 WP_000921458.1 iron chelate uptake ABC transporter family permease subunit -
MPG69_RS02785 (MPG69_02785) 576915..577682 + 768 WP_000242367.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10626.64 Da        Isoelectric Point: 9.7265

>T239224 WP_245056432.1 NZ_CP094096:574056-574328 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHNELF

Download         Length: 273 bp

>T239224 NZ_LR890643:3938624-3938842 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12279.13 Da        Isoelectric Point: 10.1678

>AT239224 WP_245056431.1 NZ_CP094096:573758-574069 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFSFLNSIKTKQKRALEKLKEIQVQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT239224 NZ_LR890643:3938223-3938597 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References