Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 1069567..1070224 Replicon chromosome
Accession NZ_CP094094
Organism Helicobacter pylori strain Hpfe084

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag MPG19_RS05125 Protein ID WP_000271050.1
Coordinates 1069567..1069851 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG19_RS05130 Protein ID WP_245065785.1
Coordinates 1069832..1070224 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG19_RS05095 (MPG19_05095) 1065498..1066265 - 768 WP_017282092.1 ABC transporter ATP-binding protein -
MPG19_RS05100 (MPG19_05100) 1066265..1067245 - 981 WP_245065779.1 iron ABC transporter permease -
MPG19_RS05105 (MPG19_05105) 1067238..1068086 - 849 WP_245065781.1 SDR family oxidoreductase -
MPG19_RS05110 (MPG19_05110) 1068227..1068751 + 525 WP_156609227.1 acyl-CoA thioesterase -
MPG19_RS05115 (MPG19_05115) 1068891..1069100 - 210 WP_245065783.1 type II toxin-antitoxin system YafQ family toxin -
MPG19_RS05120 (MPG19_05120) 1069087..1069398 - 312 WP_001133858.1 type II toxin-antitoxin system antitoxin -
MPG19_RS05125 (MPG19_05125) 1069567..1069851 - 285 WP_000271050.1 endoribonuclease VapD Toxin
MPG19_RS05130 (MPG19_05130) 1069832..1070224 - 393 WP_245065785.1 hypothetical protein Antitoxin
MPG19_RS05135 (MPG19_05135) 1070711..1072945 - 2235 WP_245065787.1 Hop family adhesin BabA -
MPG19_RS05150 (MPG19_05150) 1073445..1073966 + 522 WP_245065789.1 hypothetical protein -
MPG19_RS05155 (MPG19_05155) 1073917..1075029 - 1113 WP_245067084.1 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T239223 WP_000271050.1 NZ_CP094094:c1069851-1069567 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T239223 NZ_LR890643:c2563666-2562344 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCACTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15120.19 Da        Isoelectric Point: 7.5895

>AT239223 WP_245065785.1 NZ_CP094094:c1070224-1069832 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLERKIKKIQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GCKIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Download         Length: 393 bp

>AT239223 NZ_LR890643:c2563932-2563666 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure

References