Detailed information of TA system TA239220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 20246..21455
• Replicon: chromosome
• Accession: NZ_CP094094
• Organism: Helicobacter pylori strain Hpfe084

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG19_RS00085
• Protein ID: WP_245066177.1
• Coordinates: 20673..21455 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG19_RS00080
• Protein ID: WP_220869049.1
• Coordinates: 20246..20683 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG19_RS00065 (MPG19_00065)	16549..17118	+	570	WP_245066174.1	Eco57I restriction-modification methylase domain-containing protein	-
MPG19_RS00070 (MPG19_00070)	17133..17966	+	834	WP_245066176.1	TaqI-like C-terminal specificity domain-containing protein	-
MPG19_RS00075 (MPG19_00075)	18395..19966	+	1572	WP_245067115.1	RNA-directed DNA polymerase	-
MPG19_RS00080 (MPG19_00080)	20246..20683	+	438	WP_220869049.1	Panacea domain-containing protein	Antitoxin
MPG19_RS00085 (MPG19_00085)	20673..21455	+	783	WP_245066177.1	hypothetical protein	Toxin
MPG19_RS00090 (MPG19_00090)	21682..22869	-	1188	WP_245066179.1	transcription termination factor NusA	-
MPG19_RS00095 (MPG19_00095)	22957..24117	-	1161	WP_245066181.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30636.81 Da
• Isoelectric Point: 9.0814

>T239220 WP_245066177.1 NZ_CP094094:20673-21455 [Helicobacter pylori]
METKEENKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKPIFWFNLMVIILFVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T239220 NZ_LR890643:741134-741619 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17217.32 Da
• Isoelectric Point: 6.1241

>AT239220 WP_220869049.1 NZ_CP094094:20246-20683 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGASSIDKPKEETL
SQSLREDELETINRSIQKCNEKSYWDLVKESHKEDGAWHKSFKEDKKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239220 NZ_LR890643:740844-741137 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA