Detailed information of TA system TA023922

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3870830..3871505
• Replicon: chromosome
• Accession: NC_012880
• Organism: Dickeya dadantii Ech703

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: C6CDX2
• Locus tag: DD703_RS16415
• Protein ID: WP_015854966.1
• Coordinates: 3870830..3871258 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C6CDX3
• Locus tag: DD703_RS16420
• Protein ID: WP_015854967.1
• Coordinates: 3871239..3871505 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD703_RS16395	3866351..3867250	-	900	WP_015854962.1	site-specific tyrosine recombinase XerD	-
DD703_RS16400	3867646..3868482	+	837	WP_015854963.1	2-keto-3-deoxy-L-rhamnonate aldolase	-
DD703_RS16405	3868803..3870125	+	1323	WP_023638465.1	MHS family MFS transporter	-
DD703_RS16410	3870284..3870802	+	519	WP_015854965.1	flavodoxin FldB	-
DD703_RS16415	3870830..3871258	-	429	WP_015854966.1	protein YgfX	Toxin
DD703_RS16420	3871239..3871505	-	267	WP_015854967.1	FAD assembly factor SdhE	Antitoxin
DD703_RS16425	3871744..3872730	+	987	WP_015854968.1	tRNA-modifying protein YgfZ	-
DD703_RS16430	3872794..3873441	-	648	WP_015854969.1	hemolysin III family protein	-
DD703_RS16435	3873658..3874266	+	609	WP_015854970.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16672.47 Da
• Isoelectric Point: 10.9611

>T23922 WP_015854966.1 NC_012880:c3871258-3870830 [Dickeya paradisiaca Ech703]
VALWRCDLRVSWRMQLFSLLMHGLLLLLVLLAPWPEGYALVWLGLVTLVVFGFVRSQRNIKSRHGEISLRDDRHLRWQHR
DWDIIRSPCMLKSGILLSLRAVDGKGRQRLWLASDSMGNDEWRNLCQLLGQYHSHSTESSRR

Nucleotide

• Length: 429 bp

>T23922 NC_012880:c3871258-3870830 [Dickeya paradisiaca Ech703]
GTGGCCCTGTGGCGATGTGATTTGCGTGTATCCTGGCGGATGCAGTTGTTTTCACTGCTGATGCATGGGCTATTGCTGCT
GCTGGTGTTGCTGGCCCCCTGGCCGGAAGGGTATGCGCTGGTCTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTTG
TGCGCAGCCAGCGCAATATCAAGTCTCGCCATGGGGAAATCTCGTTGCGCGACGATCGCCATTTGCGCTGGCAGCATCGG
GACTGGGATATCATCCGGAGTCCCTGTATGTTGAAGAGCGGCATACTGCTGTCGCTACGGGCGGTGGATGGTAAAGGGCG
GCAGCGGCTGTGGCTGGCGTCGGACAGTATGGGGAATGATGAATGGCGGAACCTGTGCCAGTTGCTCGGGCAGTATCATT
CCCACTCTACGGAATCCTCCCGTCGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.97 Da
• Isoelectric Point: 6.2095

>AT23922 WP_015854967.1 NC_012880:c3871505-3871239 [Dickeya paradisiaca Ech703]
MDIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDDDKHHFVRLLQCDDPDLFNWLMNHGEPADPDLKRMVSLIQARN
KHRGPVAM

Nucleotide

• Length: 267 bp

>AT23922 NC_012880:c3871505-3871239 [Dickeya paradisiaca Ech703]
ATGGATATTGATAATAAGGCACGTATTCATTGGGCTTGCCGGCGCGGAATGCGCGAACTGGATATCTCCATCATGCCGTT
TTTCGAGCATGAATATGACACCCTGAACGATGACGATAAGCATCATTTCGTTCGTCTACTGCAGTGTGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCGGATCCTGACCTGAAACGCATGGTTTCCCTCATTCAAGCGCGAAAT
AAACATCGTGGCCCTGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: C6CDX2

Antitoxin

• AlphaFold DB: C6CDX3