Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 573158..573782 Replicon chromosome
Accession NZ_CP094092
Organism Helicobacter pylori strain Hpfe086

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG82_RS02800 Protein ID WP_245083375.1
Coordinates 573516..573782 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG82_RS02795 Protein ID WP_245083373.1
Coordinates 573158..573535 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG82_RS02770 (MPG82_02770) 568228..569340 + 1113 WP_245083367.1 hydrogenase formation protein HypD -
MPG82_RS02775 (MPG82_02775) 569291..569812 - 522 WP_245083370.1 hypothetical protein -
MPG82_RS02790 (MPG82_02790) 570337..572571 + 2235 WP_245083371.1 Hop family adhesin BabA -
MPG82_RS02795 (MPG82_02795) 573158..573535 + 378 WP_245083373.1 hypothetical protein Antitoxin
MPG82_RS02800 (MPG82_02800) 573516..573782 + 267 WP_245083375.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG82_RS02805 (MPG82_02805) 573887..574411 - 525 WP_180629647.1 acyl-CoA thioesterase -
MPG82_RS02810 (MPG82_02810) 574552..575406 + 855 WP_245083377.1 SDR family oxidoreductase -
MPG82_RS02815 (MPG82_02815) 575399..576379 + 981 WP_000921481.1 iron ABC transporter permease -
MPG82_RS02820 (MPG82_02820) 576379..577146 + 768 WP_075653295.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10246.08 Da        Isoelectric Point: 9.0170

>T239218 WP_245083375.1 NZ_CP094092:573516-573782 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADVLLVYLVKGDELILLR
LGSHSELF

Download         Length: 267 bp

>T239218 NZ_LR890643:336127-336495 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14679.58 Da        Isoelectric Point: 6.4044

>AT239218 WP_245083373.1 NZ_CP094092:573158-573535 [Helicobacter pylori]
MPNSPTQKDYTQYSEKQLFSLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT239218 NZ_LR890643:335909-336130 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References