Detailed information of TA system TA239217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 17698..18904
• Replicon: chromosome
• Accession: NZ_CP094092
• Organism: Helicobacter pylori strain Hpfe086

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG82_RS00070
• Protein ID: WP_245082529.1
• Coordinates: 18125..18904 (+)
• Length: 260 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG82_RS00065
• Protein ID: WP_140562945.1
• Coordinates: 17698..18135 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG82_RS00060 (MPG82_00060)	15850..17475	+	1626	Protein_10	RNA-directed DNA polymerase	-
MPG82_RS00065 (MPG82_00065)	17698..18135	+	438	WP_140562945.1	Panacea domain-containing protein	Antitoxin
MPG82_RS00070 (MPG82_00070)	18125..18904	+	780	WP_245082529.1	hypothetical protein	Toxin
MPG82_RS00075 (MPG82_00075)	19133..20320	-	1188	WP_245082532.1	transcription termination factor NusA	-
MPG82_RS00080 (MPG82_00080)	20407..21567	-	1161	WP_245082535.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 260 a.a.
• Molecular weight: 30391.65 Da
• Isoelectric Point: 9.3087

>T239217 WP_245082529.1 NZ_CP094092:18125-18904 [Helicobacter pylori]
METKEEDKDKKLEKIIILLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWFNLMVIILF
VIGFFGELHIIQRSVSKYL

Nucleotide

• Length: 780 bp

>T239217 NZ_LR890642:79181-79465 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17300.37 Da
• Isoelectric Point: 5.7254

>AT239217 WP_140562945.1 NZ_CP094092:17698-18135 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239217 NZ_LR890642:78943-79191 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA