Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 17899..19090 Replicon chromosome
Accession NZ_CP094091
Organism Helicobacter pylori strain Hpfe088

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPF86_RS00075 Protein ID WP_245064401.1
Coordinates 18326..19090 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPF86_RS00070 Protein ID WP_073470028.1
Coordinates 17899..18336 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF86_RS00055 (MPF86_00055) 16061..16348 + 288 WP_245064397.1 hypothetical protein -
MPF86_RS00060 (MPF86_00060) 16481..16993 + 513 WP_245064399.1 RNA-directed DNA polymerase -
MPF86_RS00065 (MPF86_00065) 17021..17674 + 654 WP_154474397.1 hypothetical protein -
MPF86_RS00070 (MPF86_00070) 17899..18336 + 438 WP_073470028.1 Panacea domain-containing protein Antitoxin
MPF86_RS00075 (MPF86_00075) 18326..19090 + 765 WP_245064401.1 hypothetical protein Toxin
MPF86_RS00080 (MPF86_00080) 19319..20506 - 1188 WP_245064403.1 transcription termination factor NusA -
MPF86_RS00085 (MPF86_00085) 20594..21754 - 1161 WP_245064405.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29877.11 Da        Isoelectric Point: 8.7873

>T239216 WP_245064401.1 NZ_CP094091:18326-19090 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNINKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKLIFWFNLMVIILFVIGFF
GELHIIQRLVSKYL

Download         Length: 765 bp

>T239216 NZ_LR890642:c65794-65312 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17246.38 Da        Isoelectric Point: 6.1226

>AT239216 WP_073470028.1 NZ_CP094091:17899-18336 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239216 NZ_LR890642:c66048-65782 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References