Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 617799..618363 Replicon chromosome
Accession NZ_CP094088
Organism Helicobacter pylori strain Hpfe092

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG40_RS02985 Protein ID WP_220959172.1
Coordinates 618097..618363 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG40_RS02980 Protein ID WP_245064231.1
Coordinates 617799..618110 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG40_RS02955 (MPG40_02955) 613603..614250 - 648 Protein_566 helicase DnaB modulator -
MPG40_RS02970 (MPG40_02970) 614693..616930 + 2238 WP_245064227.1 Hop family adhesin BabA -
MPG40_RS02975 (MPG40_02975) 617382..617723 + 342 WP_245064229.1 hypothetical protein -
MPG40_RS02980 (MPG40_02980) 617799..618110 + 312 WP_245064231.1 type II toxin-antitoxin system antitoxin Antitoxin
MPG40_RS02985 (MPG40_02985) 618097..618363 + 267 WP_220959172.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG40_RS02990 (MPG40_02990) 618470..618994 - 525 WP_245064233.1 acyl-CoA thioesterase -
MPG40_RS02995 (MPG40_02995) 619134..619976 + 843 WP_245064234.1 SDR family oxidoreductase -
MPG40_RS03000 (MPG40_03000) 619969..620949 + 981 WP_000921452.1 iron ABC transporter permease -
MPG40_RS03005 (MPG40_03005) 620949..621716 + 768 WP_000242365.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10269.22 Da        Isoelectric Point: 8.0413

>T239214 WP_220959172.1 NZ_CP094088:618097-618363 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T239214 NZ_LR890641:c65782-65366 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12357.25 Da        Isoelectric Point: 10.2819

>AT239214 WP_245064231.1 NZ_CP094088:617799-618110 [Helicobacter pylori]
MPNSPAKKDYTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNVDD

Download         Length: 312 bp

>AT239214 NZ_LR890641:c66009-65779 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References