Detailed information of TA system TA239210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 18053..19241
• Replicon: chromosome
• Accession: NZ_CP094085
• Organism: Helicobacter pylori strain Hpfe095

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG64_RS00075
• Protein ID: WP_154408718.1
• Coordinates: 18480..19241 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG64_RS00070
• Protein ID: WP_154497162.1
• Coordinates: 18053..18490 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG64_RS00060 (MPG64_00060)	16214..16501	+	288	WP_245076260.1	hypothetical protein	-
MPG64_RS00065 (MPG64_00065)	16634..17827	+	1194	WP_245076263.1	RNA-directed DNA polymerase	-
MPG64_RS00070 (MPG64_00070)	18053..18490	+	438	WP_154497162.1	Panacea domain-containing protein	Antitoxin
MPG64_RS00075 (MPG64_00075)	18480..19241	+	762	WP_154408718.1	hypothetical protein	Toxin
MPG64_RS00080 (MPG64_00080)	19470..20657	-	1188	WP_245076265.1	transcription termination factor NusA	-
MPG64_RS00085 (MPG64_00085)	20745..21905	-	1161	WP_245076267.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29787.98 Da
• Isoelectric Point: 9.0966

>T239210 WP_154408718.1 NZ_CP094085:18480-19241 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEERDKQENFFKKPIFWFNLMVTILFVIGFFG
ELHIIQRLVSKYL

Nucleotide

• Length: 762 bp

>T239210 NZ_LR890640:4130754-4131122 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17299.43 Da
• Isoelectric Point: 6.4976

>AT239210 WP_154497162.1 NZ_CP094085:18053-18490 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239210 NZ_LR890640:4130536-4130757 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATATGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA