Detailed information of TA system TA023921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3643359..3643885
• Replicon: chromosome
• Accession: NC_012880
• Organism: Dickeya dadantii Ech703

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: C6CCM9
• Locus tag: DD703_RS15460
• Protein ID: WP_015854772.1
• Coordinates: 3643580..3643885 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: C6CCM8
• Locus tag: DD703_RS15455
• Protein ID: WP_015854771.1
• Coordinates: 3643359..3643577 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD703_RS15435	3639551..3640729	-	1179	WP_015854768.1	SfnB family sulfur acquisition oxidoreductase	-
DD703_RS15440	3641014..3641706	+	693	WP_015854769.1	sulfite exporter TauE/SafE family protein	-
DD703_RS15445	3641710..3642606	-	897	WP_015854770.1	LysR family transcriptional regulator	-
DD703_RS20930	3642776..3643097	-	322	Protein_3055	IS3 family transposase	-
DD703_RS15455	3643359..3643577	+	219	WP_015854771.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
DD703_RS15460	3643580..3643885	+	306	WP_015854772.1	type II toxin-antitoxin system toxin CcdB	Toxin
DD703_RS15465	3644021..3645292	-	1272	WP_015854773.1	alanine racemase	-
DD703_RS15470	3645304..3646041	-	738	WP_015854774.1	amino acid ABC transporter ATP-binding protein	-
DD703_RS15475	3646038..3646682	-	645	WP_015854775.1	amino acid ABC transporter permease	-
DD703_RS15480	3646679..3647416	-	738	WP_015854776.1	amino acid ABC transporter permease	-
DD703_RS15485	3647467..3648303	-	837	WP_015854777.1	transporter substrate-binding domain-containing protein	-
DD703_RS15490	3648438..3648830	-	393	WP_015854778.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3639551..3657674	18123

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11555.37 Da
• Isoelectric Point: 4.8047

>T23921 WP_015854772.1 NC_012880:3643580-3643885 [Dickeya paradisiaca Ech703]
MQFFVYQYKRASHYTMFVDVQSDIVETPGRRTVMPLIEARHLSEKVNKALFPLIRIDGEDYRLMTTELSNVPVEVIGAAI
ADLGEYADEIKGAINLMFWGI

Nucleotide

• Length: 306 bp

>T23921 NC_012880:3643580-3643885 [Dickeya paradisiaca Ech703]
ATGCAATTCTTTGTTTATCAATACAAACGCGCCAGTCACTACACAATGTTTGTCGATGTACAAAGTGATATTGTCGAGAC
GCCAGGGCGGCGAACGGTCATGCCGCTTATCGAAGCGCGTCACCTGTCTGAGAAAGTGAATAAAGCGTTGTTCCCGCTGA
TCCGCATCGACGGCGAAGATTATCGGTTGATGACCACTGAACTATCCAACGTTCCCGTTGAGGTCATTGGTGCGGCTATC
GCGGATCTTGGCGAGTACGCCGATGAGATTAAAGGCGCTATTAATCTGATGTTTTGGGGGATTTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8177.14 Da
• Isoelectric Point: 8.6383

>AT23921 WP_015854771.1 NC_012880:3643359-3643577 [Dickeya paradisiaca Ech703]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW

Nucleotide

• Length: 219 bp

>AT23921 NC_012880:3643359-3643577 [Dickeya paradisiaca Ech703]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAAGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAACGATGCCATCGGCAAAGAAGCCCGCCGCATCAAAGCTGAGCAATGGAAGAAGGAAAACCGTGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAAAATGGCTCGTTTGCGGATGAAAACAGGAACTGGTGA

Structures

Toxin

• AlphaFold DB: C6CCM9

Antitoxin

• AlphaFold DB: C6CCM8