Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3643359..3643885 Replicon chromosome
Accession NC_012880
Organism Dickeya dadantii Ech703

Toxin (Protein)


Gene name ccdB Uniprot ID C6CCM9
Locus tag DD703_RS15460 Protein ID WP_015854772.1
Coordinates 3643580..3643885 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID C6CCM8
Locus tag DD703_RS15455 Protein ID WP_015854771.1
Coordinates 3643359..3643577 (+) Length 73 a.a.

Genomic Context

DD703_RS15440DD703_RS15455DD703_RS15460DD703_RS15435DD703_RS15445DD703_RS20930DD703_RS15465DD703_RS15470DD703_RS15475DD703_RS15480DD703_RS15485DD703_RS15490
Location: 3641014..3641706 (693 bp)
Type: Others
Protein ID: WP_015854769.1
Location: 3643359..3643577 (219 bp)
Type: Antitoxin
Protein ID: WP_015854771.1
Location: 3643580..3643885 (306 bp)
Type: Toxin
Protein ID: WP_015854772.1
Location: 3639551..3640729 (1179 bp)
Type: Others
Protein ID: WP_015854768.1
Location: 3641710..3642606 (897 bp)
Type: Others
Protein ID: WP_015854770.1
Location: 3642776..3643097 (322 bp)
Type: Others
Protein ID: Protein_3055
Location: 3644021..3645292 (1272 bp)
Type: Others
Protein ID: WP_015854773.1
Location: 3645304..3646041 (738 bp)
Type: Others
Protein ID: WP_015854774.1
Location: 3646038..3646682 (645 bp)
Type: Others
Protein ID: WP_015854775.1
Location: 3646679..3647416 (738 bp)
Type: Others
Protein ID: WP_015854776.1
Location: 3647467..3648303 (837 bp)
Type: Others
Protein ID: WP_015854777.1
Location: 3648438..3648830 (393 bp)
Type: Others
Protein ID: WP_015854778.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DD703_RS154353639551..3640729-1179WP_015854768.1SfnB family sulfur acquisition oxidoreductase-
DD703_RS154403641014..3641706+693WP_015854769.1sulfite exporter TauE/SafE family protein-
DD703_RS154453641710..3642606-897WP_015854770.1LysR family transcriptional regulator-
DD703_RS209303642776..3643097-322Protein_3055IS3 family transposase-
DD703_RS154553643359..3643577+219WP_015854771.1type II toxin-antitoxin system antitoxin CcdAAntitoxin
DD703_RS154603643580..3643885+306WP_015854772.1type II toxin-antitoxin system toxin CcdBToxin
DD703_RS154653644021..3645292-1272WP_015854773.1alanine racemase-
DD703_RS154703645304..3646041-738WP_015854774.1amino acid ABC transporter ATP-binding protein-
DD703_RS154753646038..3646682-645WP_015854775.1amino acid ABC transporter permease-
DD703_RS154803646679..3647416-738WP_015854776.1amino acid ABC transporter permease-
DD703_RS154853647467..3648303-837WP_015854777.1transporter substrate-binding domain-containing protein-
DD703_RS154903648438..3648830-393WP_015854778.1RidA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--3639551..365767418123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11555.37 Da        Isoelectric Point: 4.8047

>T23921 WP_015854772.1 NC_012880:3643580-3643885 [Dickeya paradisiaca Ech703]
MQFFVYQYKRASHYTMFVDVQSDIVETPGRRTVMPLIEARHLSEKVNKALFPLIRIDGEDYRLMTTELSNVPVEVIGAAI
ADLGEYADEIKGAINLMFWGI

Download         Length: 306 bp

>T23921 NC_012880:3643580-3643885 [Dickeya paradisiaca Ech703]
ATGCAATTCTTTGTTTATCAATACAAACGCGCCAGTCACTACACAATGTTTGTCGATGTACAAAGTGATATTGTCGAGAC
GCCAGGGCGGCGAACGGTCATGCCGCTTATCGAAGCGCGTCACCTGTCTGAGAAAGTGAATAAAGCGTTGTTCCCGCTGA
TCCGCATCGACGGCGAAGATTATCGGTTGATGACCACTGAACTATCCAACGTTCCCGTTGAGGTCATTGGTGCGGCTATC
GCGGATCTTGGCGAGTACGCCGATGAGATTAAAGGCGCTATTAATCTGATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8177.14 Da        Isoelectric Point: 8.6383

>AT23921 WP_015854771.1 NC_012880:3643359-3643577 [Dickeya paradisiaca Ech703]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEQWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT23921 NC_012880:3643359-3643577 [Dickeya paradisiaca Ech703]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAAGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAACGATGCCATCGGCAAAGAAGCCCGCCGCATCAAAGCTGAGCAATGGAAGAAGGAAAACCGTGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAAAATGGCTCGTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC6CCM9

Antitoxin

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Source
ID
Structure
AlphaFold DBC6CCM8

References