Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 20391..21597 Replicon chromosome
Accession NZ_CP094083
Organism Helicobacter pylori strain Hpfe096

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPG55_RS00095 Protein ID WP_245028583.1
Coordinates 20818..21597 (+) Length 260 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPG55_RS00090 Protein ID WP_245028581.1
Coordinates 20391..20828 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG55_RS00055 (MPG55_00055) 15610..15867 + 258 Protein_9 hypothetical protein -
MPG55_RS00060 (MPG55_00060) 15943..16161 + 219 WP_000906664.1 type II toxin-antitoxin system HicB family antitoxin -
MPG55_RS00065 (MPG55_00065) 16154..16348 + 195 WP_001114660.1 type II toxin-antitoxin system HicA family toxin -
MPG55_RS00070 (MPG55_00070) 16345..16977 + 633 WP_220876340.1 IS607 family transposase -
MPG55_RS00075 (MPG55_00075) 16964..18193 + 1230 WP_245028579.1 transposase -
MPG55_RS00080 (MPG55_00080) 18263..18529 + 267 Protein_14 hypothetical protein -
MPG55_RS00085 (MPG55_00085) 18540..20166 + 1627 Protein_15 RNA-directed DNA polymerase -
MPG55_RS00090 (MPG55_00090) 20391..20828 + 438 WP_245028581.1 Panacea domain-containing protein Antitoxin
MPG55_RS00095 (MPG55_00095) 20818..21597 + 780 WP_245028583.1 hypothetical protein Toxin
MPG55_RS00100 (MPG55_00100) 21826..23013 - 1188 WP_231227383.1 transcription termination factor NusA -
MPG55_RS00105 (MPG55_00105) 23101..24261 - 1161 WP_245028585.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 260 a.a.        Molecular weight: 30364.49 Da        Isoelectric Point: 6.5098

>T239209 WP_245028583.1 NZ_CP094083:20818-21597 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIKLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSSKISLSEEEKDKQENFFKKPIFWFNLMVTILF
VIGFFGELYIIQRLVSKYL

Download         Length: 780 bp

>T239209 NZ_LR890640:c3727130-3726747 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17283.56 Da        Isoelectric Point: 8.6712

>AT239209 WP_245028581.1 NZ_CP094083:20391-20828 [Helicobacter pylori]
MVNTLELAKYILKRSNKELSNLELQKTLYFTELDYIKKFGKHLVSDDFEAWKYGPIAREVYYEYRNYGANPIDKPKKETL
SQNLREDELETINRSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239209 NZ_LR890640:c3727372-3727130 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References