Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 17875..19084 Replicon chromosome
Accession NZ_CP094082
Organism Helicobacter pylori strain Hpfe097

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag MPG63_RS00080 Protein ID WP_245047265.1
Coordinates 18302..19084 (+) Length 261 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag MPG63_RS00075 Protein ID WP_075707466.1
Coordinates 17875..18312 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG63_RS00060 (MPG63_00060) 15482..16021 + 540 WP_245047259.1 hypothetical protein -
MPG63_RS00065 (MPG63_00065) 16258..16773 + 516 WP_245047261.1 RNA-directed DNA polymerase -
MPG63_RS00070 (MPG63_00070) 16956..17651 + 696 WP_245047263.1 hypothetical protein -
MPG63_RS00075 (MPG63_00075) 17875..18312 + 438 WP_075707466.1 Panacea domain-containing protein Antitoxin
MPG63_RS00080 (MPG63_00080) 18302..19084 + 783 WP_245047265.1 hypothetical protein Toxin
MPG63_RS00085 (MPG63_00085) 19314..20501 - 1188 WP_000411596.1 transcription termination factor NusA -
MPG63_RS00090 (MPG63_00090) 20589..21749 - 1161 WP_245047267.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 30492.76 Da        Isoelectric Point: 9.0870

>T239206 WP_245047265.1 NZ_CP094082:18302-19084 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKNVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWFNLMVTIL
FVIGFFGELHIIQRLVSKYL

Download         Length: 783 bp

>T239206 NZ_LR890640:c3135756-3135223 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATATGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCTGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17274.40 Da        Isoelectric Point: 6.1226

>AT239206 WP_075707466.1 NZ_CP094082:17875-18312 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIKKCNEKSYWDLVKESHKEDGAWHKSFREDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT239206 NZ_LR890640:c3136033-3135767 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References