Detailed information of TA system TA239205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 618355..619012
• Replicon: chromosome
• Accession: NZ_CP094080
• Organism: Helicobacter pylori strain Hpfe099

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: T5D7N9
• Locus tag: MPG38_RS02945
• Protein ID: WP_000271050.1
• Coordinates: 618728..619012 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG38_RS02940
• Protein ID: WP_154510323.1
• Coordinates: 618355..618747 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG38_RS02910 (613508)	613508..613744	+	237	WP_000335473.1	HypC/HybG/HupF family hydrogenase formation chaperone	-
MPG38_RS02915 (613763)	613763..614875	+	1113	WP_245101527.1	hydrogenase formation protein HypD	-
MPG38_RS02920 (614826)	614826..615471	-	646	Protein_558	helicase DnaB modulator	-
MPG38_RS02935 (615854)	615854..618079	+	2226	WP_245101528.1	Hop family adhesin BabA	-
MPG38_RS02940 (618355)	618355..618747	+	393	WP_154510323.1	hypothetical protein	Antitoxin
MPG38_RS02945 (618728)	618728..619012	+	285	WP_000271050.1	endoribonuclease VapD	Toxin
MPG38_RS02950 (619210)	619210..619734	-	525	WP_245101529.1	acyl-CoA thioesterase	-
MPG38_RS02955 (619874)	619874..620716	+	843	WP_245101530.1	SDR family oxidoreductase	-
MPG38_RS02960 (620709)	620709..621689	+	981	WP_000921438.1	iron ABC transporter permease	-
MPG38_RS02965 (621689)	621689..622456	+	768	WP_000242365.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11188.74 Da
• Isoelectric Point: 4.8896

>T239205 WP_000271050.1 NZ_CP094080:618728-619012 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Nucleotide

• Length: 285 bp

>T239205 NZ_LR890640:2533436-2533654 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15163.21 Da
• Isoelectric Point: 7.6711

>AT239205 WP_154510323.1 NZ_CP094080:618355-618747 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Nucleotide

• Length: 393 bp

>AT239205 NZ_LR890640:2533035-2533409 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• PDB: 3UI3