Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ(toxin) |
| Location | 613992..614562 | Replicon | chromosome |
| Accession | NZ_CP094076 | ||
| Organism | Helicobacter pylori strain Hpfe102 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D0K031 |
| Locus tag | MPG56_RS02945 | Protein ID | WP_000928609.1 |
| Coordinates | 614290..614562 (+) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U4RHB8 |
| Locus tag | MPG56_RS02940 | Protein ID | WP_021306657.1 |
| Coordinates | 613992..614303 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPG56_RS02915 (MPG56_02915) | 609003..610115 | + | 1113 | WP_245044213.1 | hydrogenase formation protein HypD | - |
| MPG56_RS02920 (MPG56_02920) | 610066..610638 | - | 573 | WP_245044448.1 | helicase DnaB modulator | - |
| MPG56_RS02935 (MPG56_02935) | 611092..613326 | + | 2235 | WP_245044215.1 | Hop family adhesin BabA | - |
| MPG56_RS02940 (MPG56_02940) | 613992..614303 | + | 312 | WP_021306657.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
| MPG56_RS02945 (MPG56_02945) | 614290..614562 | + | 273 | WP_000928609.1 | type II toxin-antitoxin system mRNA interferase toxin, HP0892 family | Toxin |
| MPG56_RS02950 (MPG56_02950) | 614668..615192 | - | 525 | WP_245044217.1 | acyl-CoA thioesterase | - |
| MPG56_RS02955 (MPG56_02955) | 615333..616175 | + | 843 | WP_180623202.1 | SDR family oxidoreductase | - |
| MPG56_RS02960 (MPG56_02960) | 616168..617148 | + | 981 | WP_000921438.1 | iron ABC transporter permease | - |
| MPG56_RS02965 (MPG56_02965) | 617148..617915 | + | 768 | WP_075653295.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10599.61 Da Isoelectric Point: 9.7265
>T239202 WP_000928609.1 NZ_CP094076:614290-614562 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF
Download Length: 273 bp
>T239202 NZ_LR890640:550640-550742 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 104 a.a. Molecular weight: 12359.22 Da Isoelectric Point: 10.2819
>AT239202 WP_021306657.1 NZ_CP094076:613992-614303 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNADD
MPNSPTKKDYTRYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKNIEDFKKHCENLRFKNADD
Download Length: 312 bp
>AT239202 NZ_LR890640:c550749-550604 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0L0P915 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U4RHB8 |