Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3535780..3536306 Replicon chromosome
Accession NC_012880
Organism Dickeya dadantii Ech703

Toxin (Protein)


Gene name ccdB Uniprot ID C6CCH1
Locus tag DD703_RS15150 Protein ID WP_015854715.1
Coordinates 3536001..3536306 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID C6CCH0
Locus tag DD703_RS15145 Protein ID WP_015854714.1
Coordinates 3535780..3535998 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD703_RS15125 3532001..3533260 + 1260 WP_015854709.1 integrase arm-type DNA-binding domain-containing protein -
DD703_RS15130 3533368..3533562 - 195 WP_015854710.1 DUF3950 domain-containing protein -
DD703_RS15135 3533748..3534089 + 342 WP_015854711.1 hypothetical protein -
DD703_RS15140 3534978..3535721 + 744 WP_015854713.1 hypothetical protein -
DD703_RS15145 3535780..3535998 + 219 WP_015854714.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DD703_RS15150 3536001..3536306 + 306 WP_015854715.1 type II toxin-antitoxin system toxin CcdB Toxin
DD703_RS15155 3536433..3537692 - 1260 WP_015854716.1 GIY-YIG nuclease family protein -
DD703_RS15160 3537694..3539703 - 2010 WP_015854717.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3531824..3550191 18367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11676.54 Da        Isoelectric Point: 4.8616

>T23920 WP_015854715.1 NC_012880:3536001-3536306 [Dickeya paradisiaca Ech703]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMAIPLIESHHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGEVI
ADLGGYADEIKDAINLMFWGI

Download         Length: 306 bp

>T23920 NC_012880:3536001-3536306 [Dickeya paradisiaca Ech703]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGTCATTACAAAATGTTTGTCGATGTGCAAAGTGATATTGTCGAGAC
TCCCAAGCGGCGTATGGCTATCCCGCTTATCGAATCGCACCACCTGTCTGAGAAAGTGAATAAAACGCTGTTCCCGCTGA
TTCGCATCGATGGGGAAGATTATCGGCTGATGACCACTGAGCTATCGAGCGTTCCTGTTGAGGTCATTGGTGAAGTTATC
GCGGATCTTGGCGGCTACGCAGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8165.18 Da        Isoelectric Point: 8.6801

>AT23920 WP_015854714.1 NC_012880:3535780-3535998 [Dickeya paradisiaca Ech703]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEVWRKENREGMEEVARLIAQHGSFADENRNW

Download         Length: 219 bp

>AT23920 NC_012880:3535780-3535998 [Dickeya paradisiaca Ech703]
ATGAAACACCGTGTCAGCGTTACCGTGGACAAGGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGCATCAAAGCTGAAGTGTGGAGAAAGGAAAACCGCGAAGGGATGGAGG
AAGTCGCCCGACTCATCGCACAGCATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8QIT0

Antitoxin

Source ID Structure
AlphaFold DB C6CCH0

References