Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 613264..613888 Replicon chromosome
Accession NZ_CP094071
Organism Helicobacter pylori strain Hpfe106

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPG62_RS02925 Protein ID WP_274595237.1
Coordinates 613676..613888 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG62_RS02920 Protein ID WP_245099834.1
Coordinates 613264..613641 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG62_RS02895 (MPG62_02895) 608473..609585 + 1113 WP_245099828.1 hydrogenase formation protein HypD -
MPG62_RS02900 (MPG62_02900) 609536..610057 - 522 WP_245099830.1 hypothetical protein -
MPG62_RS02915 (MPG62_02915) 610561..612783 + 2223 WP_245099832.1 Hop family adhesin BabA -
MPG62_RS02920 (MPG62_02920) 613264..613641 + 378 WP_245099834.1 hypothetical protein Antitoxin
MPG62_RS02925 (MPG62_02925) 613676..613888 + 213 WP_274595237.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG62_RS02930 (MPG62_02930) 613993..614517 - 525 WP_245099836.1 acyl-CoA thioesterase -
MPG62_RS02935 (MPG62_02935) 614657..615499 + 843 WP_245099838.1 SDR family oxidoreductase -
MPG62_RS02940 (MPG62_02940) 615492..616472 + 981 WP_000921438.1 iron ABC transporter permease -
MPG62_RS02945 (MPG62_02945) 616472..617239 + 768 WP_000242366.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-70)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8161.56 Da        Isoelectric Point: 7.2773

>T239198 WP_274595237.1 NZ_CP094071:613676-613888 [Helicobacter pylori]
MNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILVRLGSHSELF

Download         Length: 213 bp

>T239198 NZ_LR890633:c55378-54962 [Klebsiella pneumoniae]
GTGAACAAAATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGGGGTCACCGCATTGTGGTTTCGGCCATTACCTACGCCGAGATGCGCTTCGGCGCCACCGGGC
CGAAGGCCGCGCCGCGTCACGTCCAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCATGGCCGGCACGCCGATTGGCCCGAACGACACGGCGATTGC
CGGACACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14713.69 Da        Isoelectric Point: 8.4512

>AT239198 WP_245099834.1 NZ_CP094071:613264-613641 [Helicobacter pylori]
MPNTTAKKDYTQYSEKQLFNLIHQLERKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNELLQKISQAFDNKRDCCL
GYEIPNIETQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQS

Download         Length: 378 bp

>AT239198 NZ_LR890633:c55605-55375 [Klebsiella pneumoniae]
ATGCGCACAGTCTCTATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGGGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References