Detailed information of TA system TA239195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1096339..1096963
• Replicon: chromosome
• Accession: NZ_CP094070
• Organism: Helicobacter pylori strain Hpfe107

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MPG33_RS05330
• Protein ID: WP_000916179.1
• Coordinates: 1096339..1096605 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG33_RS05335
• Protein ID: WP_245049608.1
• Coordinates: 1096586..1096963 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG33_RS05300 (MPG33_05300)	1092598..1092777	-	180	Protein_1044	iron ABC transporter ATP-binding protein	-
MPG33_RS05305 (MPG33_05305)	1092790..1092969	-	180	Protein_1045	iron ABC transporter ATP-binding protein	-
MPG33_RS05310 (MPG33_05310)	1092982..1093749	-	768	WP_000242366.1	ABC transporter ATP-binding protein	-
MPG33_RS05315 (MPG33_05315)	1093749..1094729	-	981	WP_000921482.1	iron ABC transporter permease	-
MPG33_RS05320 (MPG33_05320)	1094722..1095570	-	849	WP_245062332.1	SDR family oxidoreductase	-
MPG33_RS05325 (MPG33_05325)	1095711..1096235	+	525	WP_001135615.1	hotdog domain-containing protein	-
MPG33_RS05330 (MPG33_05330)	1096339..1096605	-	267	WP_000916179.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MPG33_RS05335 (MPG33_05335)	1096586..1096963	-	378	WP_245049608.1	hypothetical protein	Antitoxin
MPG33_RS05340 (MPG33_05340)	1097761..1099992	-	2232	WP_245062342.1	Hop family adhesin BabA	-
MPG33_RS05355 (MPG33_05355)	1100495..1101016	+	522	WP_245062344.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10329.21 Da
• Isoelectric Point: 9.6292

>T239195 WP_000916179.1 NZ_CP094070:c1096605-1096339 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T239195 NZ_LR890632:4349338-4349871 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGATTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14610.63 Da
• Isoelectric Point: 8.7066

>AT239195 WP_245049608.1 NZ_CP094070:c1096963-1096586 [Helicobacter pylori]
MPNSPTKKDCTQYSEKQLFNLIHQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDNKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT239195 NZ_LR890632:4349061-4349327 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA