Detailed information of TA system TA239194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 607084..607741
• Replicon: chromosome
• Accession: NZ_CP094067
• Organism: Helicobacter pylori strain Hpfe108

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: T5D7N9
• Locus tag: MPG11_RS02945
• Protein ID: WP_000271050.1
• Coordinates: 607457..607741 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG11_RS02940
• Protein ID: WP_245049888.1
• Coordinates: 607084..607476 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG11_RS02920 (MPG11_02920)	603036..603557	-	522	WP_245053028.1	hypothetical protein	-
MPG11_RS02935 (MPG11_02935)	604075..606309	+	2235	WP_245053037.1	Hop family adhesin BabA	-
MPG11_RS02940 (MPG11_02940)	607084..607476	+	393	WP_245049888.1	hypothetical protein	Antitoxin
MPG11_RS02945 (MPG11_02945)	607457..607741	+	285	WP_000271050.1	endoribonuclease VapD	Toxin
MPG11_RS02950 (MPG11_02950)	607937..608461	-	525	WP_120845779.1	acyl-CoA thioesterase	-
MPG11_RS02955 (MPG11_02955)	608601..609455	+	855	WP_245053039.1	SDR family oxidoreductase	-
MPG11_RS02960 (MPG11_02960)	609448..610428	+	981	WP_000921452.1	iron ABC transporter permease	-
MPG11_RS02965 (MPG11_02965)	610428..611195	+	768	WP_120824486.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11188.74 Da
• Isoelectric Point: 4.8896

>T239194 WP_000271050.1 NZ_CP094067:607457-607741 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Nucleotide

• Length: 285 bp

>T239194 NZ_LR890632:4217347-4217631 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15092.20 Da
• Isoelectric Point: 8.4847

>AT239194 WP_245049888.1 NZ_CP094067:607084-607476 [Helicobacter pylori]
MPNSPTKKDYTRYNEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDNKRDCCL
GCKIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Nucleotide

• Length: 393 bp

>AT239194 NZ_LR890632:4217115-4217357 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• PDB: 3UI3