Detailed information of TA system TA239192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 18098..19322
• Replicon: chromosome
• Accession: NZ_CP094067
• Organism: Helicobacter pylori strain Hpfe108

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MPG11_RS00085
• Protein ID: WP_121292404.1
• Coordinates: 18525..19322 (+)
• Length: 266 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MPG11_RS00080
• Protein ID: WP_024948607.1
• Coordinates: 18098..18535 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG11_RS00060 (MPG11_00060)	15704..16237	+	534	WP_245049302.1	hypothetical protein	-
MPG11_RS00065 (MPG11_00065)	16254..16946	+	693	WP_245049304.1	hypothetical protein	-
MPG11_RS00070 (MPG11_00070)	16954..17193	+	240	WP_245049306.1	RNA-directed DNA polymerase	-
MPG11_RS00075 (MPG11_00075)	17221..17874	+	654	WP_245052585.1	hypothetical protein	-
MPG11_RS00080 (MPG11_00080)	18098..18535	+	438	WP_024948607.1	Panacea domain-containing protein	Antitoxin
MPG11_RS00085 (MPG11_00085)	18525..19322	+	798	WP_121292404.1	hypothetical protein	Toxin
MPG11_RS00090 (MPG11_00090)	19549..20736	-	1188	WP_245052587.1	transcription termination factor NusA	-
MPG11_RS00095 (MPG11_00095)	20824..21984	-	1161	WP_245052589.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 266 a.a.
• Molecular weight: 31204.58 Da
• Isoelectric Point: 9.6972

>T239192 WP_121292404.1 NZ_CP094067:18525-19322 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFIMAFIALFFGNILYLLFSFLSKISLSSKISLSKEERDKQENFFKKPIFWFNLMVIILF
VIGFVGERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 798 bp

>T239192 NZ_LR890632:c3289014-3288646 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17317.36 Da
• Isoelectric Point: 5.3873

>AT239192 WP_024948607.1 NZ_CP094067:18098-18535 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVSREVYYEYRNYGANSIDKPKEETL
SQDLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT239192 NZ_LR890632:c3289232-3289011 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA