Detailed information of TA system TA239191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 582927..583497
• Replicon: chromosome
• Accession: NZ_CP094066
• Organism: Helicobacter pylori strain Hpfe110

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0K031
• Locus tag: MPG46_RS02850
• Protein ID: WP_000928609.1
• Coordinates: 583225..583497 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MPG46_RS02845
• Protein ID: WP_120923865.1
• Coordinates: 582927..583238 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG46_RS02815 (MPG46_02815)	578363..579013	-	651	Protein_536	helicase DnaB modulator	-
MPG46_RS02830 (MPG46_02830)	579396..581615	+	2220	WP_245014656.1	Hop family adhesin BabA	-
MPG46_RS02835 (MPG46_02835)	582101..582493	+	393	WP_245014657.1	hypothetical protein	-
MPG46_RS02840 (MPG46_02840)	582474..582758	+	285	WP_000271050.1	endoribonuclease VapD	-
MPG46_RS02845 (MPG46_02845)	582927..583238	+	312	WP_120923865.1	type II toxin-antitoxin system antitoxin	Antitoxin
MPG46_RS02850 (MPG46_02850)	583225..583497	+	273	WP_000928609.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	Toxin
MPG46_RS02855 (MPG46_02855)	583573..584097	-	525	WP_180387463.1	acyl-CoA thioesterase	-
MPG46_RS02860 (MPG46_02860)	584238..585080	+	843	WP_245014658.1	SDR family oxidoreductase	-
MPG46_RS02865 (MPG46_02865)	585073..586053	+	981	WP_000921481.1	iron ABC transporter permease	-
MPG46_RS02870 (MPG46_02870)	586053..586820	+	768	WP_050828715.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10599.61 Da
• Isoelectric Point: 9.7265

>T239191 WP_000928609.1 NZ_CP094066:583225-583497 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T239191 NZ_LR890632:c2801584-2801174 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12279.04 Da
• Isoelectric Point: 9.9013

>AT239191 WP_120923865.1 NZ_CP094066:582927-583238 [Helicobacter pylori]
MPNTTAEKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT239191 NZ_LR890632:c2801831-2801565 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0L0P915