239190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 582101..582758 Replicon chromosome
Accession NZ_CP094066
Organism Helicobacter pylori strain Hpfe110

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag MPG46_RS02840 Protein ID WP_000271050.1
Coordinates 582474..582758 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPG46_RS02835 Protein ID WP_245014657.1
Coordinates 582101..582493 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG46_RS02810 (MPG46_02810) 577300..578412 + 1113 WP_245014655.1 hydrogenase formation protein HypD -
MPG46_RS02815 (MPG46_02815) 578363..579013 - 651 Protein_536 helicase DnaB modulator -
MPG46_RS02830 (MPG46_02830) 579396..581615 + 2220 WP_245014656.1 Hop family adhesin BabA -
MPG46_RS02835 (MPG46_02835) 582101..582493 + 393 WP_245014657.1 hypothetical protein Antitoxin
MPG46_RS02840 (MPG46_02840) 582474..582758 + 285 WP_000271050.1 endoribonuclease VapD Toxin
MPG46_RS02845 (MPG46_02845) 582927..583238 + 312 WP_120923865.1 type II toxin-antitoxin system antitoxin -
MPG46_RS02850 (MPG46_02850) 583225..583497 + 273 WP_000928609.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family -
MPG46_RS02855 (MPG46_02855) 583573..584097 - 525 WP_180387463.1 acyl-CoA thioesterase -
MPG46_RS02860 (MPG46_02860) 584238..585080 + 843 WP_245014658.1 SDR family oxidoreductase -
MPG46_RS02865 (MPG46_02865) 585073..586053 + 981 WP_000921481.1 iron ABC transporter permease -
MPG46_RS02870 (MPG46_02870) 586053..586820 + 768 WP_050828715.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T239190 WP_000271050.1 NZ_CP094066:582474-582758 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T239190 NZ_LR890632:c1536690-1536588 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15077.12 Da        Isoelectric Point: 8.2482

>AT239190 WP_245014657.1 NZ_CP094066:582101-582493 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELDKRDQNFKDKIDALNGLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNGVNLTQIDSLDDLTNELKRENGKGFENVCFSV

Download         Length: 393 bp

>AT239190 NZ_LR890632:1536581-1536726 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure

References