Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 582624..583248 Replicon chromosome
Accession NZ_CP094065
Organism Helicobacter pylori strain Hpfe112

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MPF94_RS02800 Protein ID WP_025445934.1
Coordinates 582982..583248 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MPF94_RS02795 Protein ID WP_180630648.1
Coordinates 582624..583001 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF94_RS02770 (MPF94_02770) 577873..578985 + 1113 WP_245022404.1 hydrogenase formation protein HypD -
MPF94_RS02775 (MPF94_02775) 578936..579580 - 645 Protein_531 helicase DnaB modulator -
MPF94_RS02790 (MPF94_02790) 579979..582210 + 2232 WP_245022405.1 Hop family adhesin BabA -
MPF94_RS02795 (MPF94_02795) 582624..583001 + 378 WP_180630648.1 hypothetical protein Antitoxin
MPF94_RS02800 (MPF94_02800) 582982..583248 + 267 WP_025445934.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MPF94_RS02805 (MPF94_02805) 583355..583879 - 525 WP_212883249.1 acyl-CoA thioesterase -
MPF94_RS02810 (MPF94_02810) 584022..584864 + 843 WP_245022406.1 SDR family oxidoreductase -
MPF94_RS02815 (MPF94_02815) 584857..585837 + 981 WP_000921438.1 iron ABC transporter permease -
MPF94_RS02820 (MPF94_02820) 585837..586604 + 768 WP_219037263.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10246.08 Da        Isoelectric Point: 9.0170

>T239188 WP_025445934.1 NZ_CP094065:582982-583248 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T239188 NZ_LR890625:c224249-223779 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTAATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14701.63 Da        Isoelectric Point: 6.9590

>AT239188 WP_180630648.1 NZ_CP094065:582624-583001 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT239188 NZ_LR890625:c224689-224246 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTCCTGGGGCAAATCAATGAAGGCCTGGACGGGAAGGTGGCAAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCTTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAATGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACACGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References